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- Michigan
- Michigan State University
- Pharmacology
- Pharmacology 563
- Prokop
- 3: antibiotics cont.
3: antibiotics cont.
Pharmacology 563 with Prokop at Michigan State University
About this deck
By: Michael Lenze
Created: 2011-06-12
Size: 37 flashcards
Views: 4
Created: 2011-06-12
Size: 37 flashcards
Views: 4
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MSSA/MSSE
- First gen Cephalosporin
- Cefuroxime 2nd gen
- Ceftazadime - 3rd Gen
- Cefepime - 4th Gen
- Advanced Gen
- Cipro and levofloxacin
PSA
- Monobactams (Azteonam)
- Ceftazadime - Beta lactam
- Cefepime - Beta lactam
MRSA
Tigecycline
VRSA
Tigecycline
VISA
Tigecycline
Drugs that can cross CNS withOUT inflammation
- Chloramphenicol
- Cycloserine
- Ethionamide
- Isoniazid
- Metrromnidazole
- Pyrazinamide
- Rifampin
- Sulfonamides
- Trimethoprim
Drugs that can Cross BBB with inflammation?
- Ampicillin
- Pencillin
- Pipoeracillin
- Monobactams
- Carbapenams
- 3rd & 4th Gen Cephalosporin
- Fluoroquinolones
- Vancomycin
- Big Guns
Which drugs bind to 50S and inhibits peptide bonds
Chloramphenicol
Which drugs binf to 50S and prevents translocation movement of ribsome alongmRNA
Erythromycin (Macrolides)
Which change the shape of the 30S portion causeing code on mRNA to be read incorrectly
Streptomycin
Which interfere with attachment of tRNA to mRNA-ribosome complex
tetracyclines
the two tetracyclines that do not need to be renally dose adj
Doxycycline and Tigecycline
Macrolides for Pneumococci
Erythromycin = Clarithromycin > Azithromycin
Macrolides resistance
- reduced permeability or active efflux
- production of esterases
- Modification of ribosomal binding (constitutive methylase)
only macrolide to be renally adj
Clarithromycin
CLindamycins activiry
G+ anaerobes (staph and pnenmococci)
G- anaerobes (Bacteroides)
Clindamycin side effects
- Skin rash
- N/D
- pseudomembrane coliltis secondary to C. difficile
The streptogramin drugs
- Dalfopristin (early) & Quinupristin (late)
- The BIG GUNS
- synergistic
Streptogramins side effects
- Pain at infusion site
- Arthralgia-myalgia syndrom
- DDI (inhibits CYP-450 3A4)
Linezolid
- Big Gun Bacteriostatic, Bactericidal against Strep
- Inhibits protein syn by binding 23S
- no cross resistance
Linezolid activity
- G+ (staph, strep, entero, listeria)
- reserved for vancomycin resisant E. Faecium
- Nosocomial pneumonia
- Skin infection
linezolids side effects
- Thrombocytopenia
- neutropenia
- serotonin syndrome
Protein syn inhibitors
must cross cell wall and cell membrane
often used with a cell wall inhibitor
Norfloxacin
Group 1 fluoroquinolones
G-, limited G+
Ciprofloxacin and levofloxacin
Group 2 fluoro
G--, moderate G+ activity
Moxifloxacin
- Group 3 fluoro
- Moderate G--
- improved G+ activity
only fluoroquinolone that does not need to be renally adj
Moxifloxacin (contraindicated in pt with hepatic failure)
fluoroquinolone side effects
- Photosensitivity
- QT prolongation
- Tendonitis or tendon rupture
- May damage growth of cartilage
Fluoroq clinical use
- UTI
- Prostatitis
- Gastroenteritis
- Osteomyelitis
- Antrax
bloack the syntesis of folate by blocking p-aminobenzoic acid
Sulfonamides (analog of PABA)
trimethoprim (inh. dihydrofolate reducatase)
antifolate drugs activity
G+, no group D strep activity and resisitance is inc.
G-- but not PSA or neisseria
Antifolate drugs side effects
- Rash
- fever
- thrombocytopenia
- Megaloblastic anemia
- Jaundice and Kernicterus in infants
- Disulfiram rxn
- Avoid in pt w/ G6PD deficiency
Antifolate drug use
- UTI
- Pneumocystis jiroveci pneumonia (AIDS)
- toxoplasmosis
- nocardiosis
About this deck
By: Michael Lenze
Created: 2011-06-12
Size: 37 flashcards
Views: 4
Created: 2011-06-12
Size: 37 flashcards
Views: 4
About StudyBlue
STUDYBLUE makes things that make you better at school.
Things like online flashcards with photos and audio.
Things like personalized quizzes and friendly reminders about when (and what) to study next.
Think of it as a digital backpack™: access to all of your study materials online and on your phone.
STUDYBLUE exists to make studying efficient and effective for every student, for free. Join us.
“Simply amazing. The flash cards are smooth, there are many different types of studying tools, and there is a great search engine. I praise you on the awesomeness.”
Dennis
Dennis