Anti-Microbials, random pts

Medicine Dit Class with Meyer at University of Chapel Hill

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By: John Meyer
Created: 2012-06-03
Size: 28 flashcards
Views: 14

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Sulfa drugs, give the quick version

anything w sulfa in the name
diuretics(loops, thiazides, and CAIs)
Probenecid, Celecoxib, and Sumatriptan

4 clinical uses for TMP/SMX

UTIs, MRSA, Shigella/Salmonella, and PCP prophylaxis

woman w UTI while pregnant, what drug to use?

Nitrofurantoin

for E. coli or S. saprophyticus

Clinical uses for ampicillin and amoxicillin

Gram +s and Gram - rods(HELPSS)

H. influ
E. coli
Listeria(which is actually a Gram + rod)
Proteus
Salmonella and Shigella

best tx for neonatal infections

Ampicillin w/gentamycin (to fight the E. coli, GBS, and Listeria)

3 penicillins that can be used to tx Pseudomonas infections

Ticarcillin, carbenicillin, pipercillin

Things you can't use cephalosporins against

LAME = Listeria, Atypicals(mycoplasma and chlamydia), MRSA, and Enterococci

What are clinical uses for Cefazolin and Cephalexin?

these are 1st gen

Gram + cocci +
PEcK = Proteus, E. coli, and Klebsiella

conjucation, what bacteria like to do it

Gram - rods (like Pseudomonas, Salmonella, Shigella, E. coli, Klebsiella)

Transposition, what is it and what gets transposed

Where gene just can pick up and leave

Multi-drug resistance

Clinical uses of Cefoxitin, Cefaclor, and Cefuroxime

2nd gen cephalosporins

Gram +s and
HEN PEcKS

just adding H. flu, Enterobacter, Neisseria and Serratia
Still have Proteus, E. coli, and Klebsiella

3 big uses for Ceftriaxone

Meningitis, Community Acquired Pneumo, and Gonorrhea

Two cephalosporins that cover Pseudomonas

Ceftazadime(a 3rd gen) and your big gun(Cefapime = 4th gen)

Loops + aminoglycoside, side effect

ototoxicity

Aminoglycoside + cephalosporin, side effect

nephrotoxicity

Drug of choice for penicillin-allergic pts and those w renal insufficiency who cannot tolerate aminoglycosides

Aztreonam(binds to PBP3, kind of an aminoglycoside pretender)

for Gram - only

SEs of INH

think Injures Neurons and Hepatocytes = INH. neurotoxicity, hepatotoxicity, lupus

vitB6 can help w hepatotoxicity and lupus

What is needed to convert INH to active metabolite

bacteria catalase-peroxidase, KatG

MOA of pyrazinamide

inhibits mycolic acid production by blocking mycobacterial fatty acid synthase 1; effective in acidic pH of phagolysosomes, where TB engluged by macrophages

SE of pyrazinamide

hyperuricemia

and a little hepatotoxicity

Ethambutuol, moa and SE

Only bacteriostatic TB drug

decreased carb polymerization of mycabacterium cell wall by blocking arabinosyltransferase
SE = optic neuropathy (red-green color blindness)

when can Linezolid be used, and where does it bind

MFSA and VRE

binds 23s RNA

drugs w ototoxicity and nephrotoxicity as side effect

Cisplatin, Aminoglycosides, Vancomycin, and Loops

Clinical uses for tetracyclines

"VACUM THe Bed Room"

V. cholerae, Acne, Chlamydia, Ureaplasma, Mycoplasm pneumo, Tularemia, H. pylori, Borrelia burgoderfi, and Rickettsia

contraindications for tetracyclines

Don't take w any divalent cations

also not for kids/pregnant women

clinical uses for macrolides

"PUS"

Pnemonia(atypical), URIs, and STDs

name the 2 main SEs of chlormaphenicol

Aplastic anemia and Gray-baby syndrome(due to increased UDP-glucoronyl transferase)

Drugs effective against pseudomonas

Fluoroquinoone, Cefepime, Aztreonam, Aminoglycosides, extended spectrum penicillins(like pipercillin)

About this deck

By: John Meyer
Created: 2012-06-03
Size: 28 flashcards
Views: 14

About StudyBlue

“Simply amazing. The flash cards are smooth, there are many different types of studying tools, and there is a great search engine. I praise you on the awesomeness.”
Dennis