1. Absolute lifetime risk of breast caner to age 90
2. Five year breast cancer risk
Developed to determine eligibility for tamoxifen.
No applicable in women with LCIS or DCIS.
- ductal carcinoma in situ
-malignant cells confined to a duct
- no stromal invasion
- hallmark clustered microcalcification on mammogram
-curable with resection alone
Dose: 60 mg Qday
Favorable SE: decrease lipid: TC and LDL
1. increase risk of thromboembolic events (DVT, PE, MI, stroke) Avoid if risk of blood clots
SE: hot flashes, flushing, HTN, mood changes, amenorrhea, vaginal bleeding/discharge, skin changes
-first lymph nodes to receive malgnant cells
-in breast cancer-pectoral or parasternal nodes
-removed and examined during surgery to determine if complete dissection of axillary lymph nodes needs to be done