Cardiac Muscle Lecture 30

StudyBlue printing of Cardiac Muscle Lecture 30 html, body, div, span, applet, object, iframe, h1, h2, h3, h4, h5, h6, p, blockquote, pre, a, abbr, acronym, address, big, cite, code, del, dfn, em, font, img, ins, kbd, q, s, samp, small, strike, strong, sub, sup, tt, var, b, u, i, center, fieldset, form, label, legend, table, caption, tbody, tfoot, thead, tr, th, td { margin: 0; padding: 0; border: 0; outline: 0; font-size: 100%; background: transparent; } body { line-height: 1; } blockquote, q { quotes: none; } blockquote:before, blockquote:after, q:before, q:after { content: ''; content: none; } /* remember to define focus styles! */ :focus { outline: 0; } /* remember to highlight inserts somehow! */ ins { text-decoration: none; } del { text-decoration: line-through; } /* tables still need 'cellspacing="0"' in the markup */ table { border-collapse: collapse; border-spacing: 0; } /* end RESET */ .header { min-width:800px; } .logo { padding:6px 20px 2px 20px; margin:0; font-size:25px; font-weight:bold; color:#808285; position:relative; border-bottom: 1px solid #c5c5c5; } .logo-blue { color:#70adc4; } .logo-desc { font-weight:normal; font-size:19px; color:#cccccc; margin-top:50px; position:absolute; display: none; } .back-button { position:absolute; top:20px; right:20px; font-size:13px; line-height:25px; color:rgb(0,175,225); font-weight:normal; } .back-button a { color:rgb(0,175,225); } .instructions { padding:0; margin:0; width:100%; position:relative; color:rgb(100,100,100); } .step-holder { border-left:1px solid #ededed; margin-left:20px; } .steps { padding:15px 0; float:left; width:24%; border-right:1px solid #ededed; text-align:center; } .steps-01 { } .steps-02 { } .steps-03 { } .steps-04 { } .label { padding:5px 10px; } .print-button { } .print-button a { background-color:rgb(0,175,225); color:white; line-height: 19px; padding:9px 8px 5px 30px; font-size:14px; text-decoration:none; background-image: url(images/printer.png); background-repeat: no-repeat; background-position: 7px 50%; -moz-border-radius: 5px; -webkit-border-radius: 5px; } .print-button a:hover { background-color:black; } .theNote .content { width: 8.0in !important; margin: 5px auto; padding:20px; background-color:white; } .theNote .header { border-bottom: 1px dashed #C8C8C8; font-size: 17px; padding: 0 0 10px; line-height: 19px; color: #00ADE1; min-width:500px; } .theNote .body { font-size: 14px; line-height: 19px; padding: 10px 0; } .theNote{ padding:6px 0; clear:both; background-color: rgb(200,200,200); } .theNote h3{ color: rgb(100,100,100); } .theNote h1, .theNote h3{ background-color:white; padding:2px 20px; width:8.0in !important; margin: 0 auto; font-size: 15px; } .theNote h1{ padding-top: 10px; font-size: 15px; } .theNote h1:first-child{ font-size: 20px; } .theNote h3 { font-size: 14px; font-weight: normal; } #options { border: 3px double #ccc; padding: 5px 12px; margin: 10px 50px 10px 20px; float: left; } #info { border-top: 1px solid #ccc; padding-top: 5px; font-style: italic; } li { margin: 5px 10px 5px 25px; } ul li { list-style: disc; } ol li { list-style: decimal; } img { border: 0; } table { clear: both; width: 100%; border: 1px solid #c5c5c5; border-width: 1px 0; margin: 0; page-break-after: always; } table#page { page-break-after: auto; } td { text-align: center; font-size: 12px; border-bottom: 1px dashed #c5c5c5; height: 1.75in; width: 50%; padding-left: 15px; } .leftside { border-right: 1px solid #cccccc; padding: 0 15px 0 0; } .bottom td { border-bottom: none; } .clearfix { clear:both; line-height:1px; height:1px; } img { max-width:80%; max-height:150px; margin:20px; } @media print {.header { display: none; } .content .header{ display:inherit; } table { border: 1px dashed #bbb; border-width: 1px 0; } .theNote{ background-color:white; } } Compare and contrast the light microscopic characterisitcs of skeletal and cardiac muscle with regard to number of nuclei per cell placement of nuclei in cells striations branching of cells Be able to recognize these features in appropiate histological preparations CP pg 81 Id a single cell in a LM view of cardiac M please see lab and plate 4 pg 313 Id the branching of the cells in LM view of cardiac M pg 315 Both plates Define ventricular working cells CP pg 82 and SS 30 pg 3 Define cardial nodal cells and purkinje fibers SS30 pg 3 and CP pg 82 Compare and constract the light microscope characteristics of ventricular working cells and Purkinje fibers pg 313-314 Name the major organelles of cardiac working muscle. ID in EM SS 30 pg 3 and CP pg 83 Name the major components of myofibrils CP pg 84, SS30 pg 3 Explain how the contents of myofibrils results in strations visible under light microscope SS 30 pg 3 Name the organelles that take up the most of the volume of working cardiac M SS 30 pg 3 Describe hot T-tubules and sarcoplasmic reticulum play analogous roles in excitation contraction coupling in cardiac and skeletal M CP pg 84 Lec 30, SS 30 pg 4 Compare and contrast the microanatomy and the function of T tubule and SR in cardiac and skeletal M CP pg 85 and SS30 pg 4 state the location of intercalated discs in cardiac muscle and name. Describe the specialized structures and their functions CP pg 85 and SS30 pg 4 state the location of secretory granules and their contents CP pg 86 and SS30 pg 5 Review the skeletal muscle development at the level of cross bridge cycling, and apply it to cardiac M see skeletal section Explain why force adjustment by means of temporal and spatial summation does not occur in cardiac M CP pg 88 and SS30 pg 6 List the two mechanisims by which force of contraction is adjusted in cardiac M CP pg 85 and SS30 pg 4 Describe the relationship btw active force development and cardiac muscle length CP pg 89 Describe the relationship between passive force development and cardiac muscle length CP pg 88 Explan why in the heart,cardiac muscle never operates on the descending length of the length-active tension cuve CP pg 88 and SS30 pg 6 Describe the mechanisms responsible fot the ascending and descending limbs of the length active tension curve SS30 pg 6 Define cardiac M contractility CP pg 89 Draw a graph showing changes in conrtactility CP pg 89-90 Describe the signaling pathway by which norepinephrine increases contractility CP pg 89-90 Draw a graph showing the effect of NE on cardiac force development CP pg 90 Describe the three events that accompany an increase in CAMP? CP pg 90-91 Draw a graph showing how NE changes the relationship btw force development and velocity of shortening CP pg 90 Draw a graph showing how Ne changes the rate of relaxation of cardiac M Describe the cellular mechanism for the increased in relaxation CP pg 91 Describe the effect of increased frequency of contraction on contractility; the mech for the increase contractility caused by increase frequency of contraction pg 92 Describe how digitalis increased cardiac contractility pg92 Explain why increased contractility caused by increased frequency and digitalis do not cause increase rate of contraction and relaxation pg 92 describe the causes of increased and decreased contractility pg93 Define postitive and negative inotropic agents pg93 Describe the effects of long term over stimulation of cardiac muscle by norepinephrine pg93 With reference to john jump describe the genetic change underlying of this case of hyperthophic cardiomiopathy describe the genetic mutation foun in Jon jumps brother heart could result in reduce velocity of contraction Desceribe how the gross anatomy of john jumpers brothers heart differs from normal Describe the how the microscopic (light and EM) anatomy of John Jump's brother's heart differ from normal look at case its highlighted