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- Maryland
- Johns Hopkins University
- Public Health
- Public Health 280.335
- Trush
- case studies in metals
case studies in metals
Public Health 280.335 with Trush at Johns Hopkins University
About this deck
By: Lauren Burke
Created: 2011-10-19
Size: 39 flashcards
Views: 3
Created: 2011-10-19
Size: 39 flashcards
Views: 3
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what are the FIVE metals in the top 20 hazardous substances
arsenic
lead
mercury
cadmium
chromium hexavalent
lead
mercury
cadmium
chromium hexavalent
what is a source of endogenous protection against metal toxicity?
metallothionein
metallothionein has a high...
cysteine content and high metal content
what is the function of metallothionein
metal detoxification
metal homeostasis
metal homeostasis
in ________________ the closing of ___________ in the 1980 was a major blow to the towns economy but left behind contamination of soil and water.
Leadville Colorado
Climax Mine
Climax Mine
Climax Mine was so polluted it became a site for...
EPA superfunds
what are the heath effects of cadmium exposure
osteoporosis in women
height loss in men
kidney damage
elevated blood pressure
cardiovascular diseases
itai-itai disease
height loss in men
kidney damage
elevated blood pressure
cardiovascular diseases
itai-itai disease
what was the most major environmental disaster in Europe
100 million ton slag heap of lean, zinc, and arsenic from trepeca smelter in Kosovo
What are the sources of mercury?
degassing of earths crust
fossil fuels
industrial release
diet
dental amalgams
fossil fuels
industrial release
diet
dental amalgams
what is the usual exposure to mercury resulting from food?
2ug/day
what levels of mercury were people exposed to in Iraq
500 ug/day
where was the source of the mercury exposure in Iraq
HOMEMADE BREADS - shipment of wheat and barley treated with alkyl fungicide (1971)
What event happened in minimata japan?
chronic exposure to 50ug/day from fish
what are the new EPA FDA advisories for consumption of fish (2004)
Don't eat shark, swordfish, king mackerel or tilefish
no more than 12 ounces or 2 meals of fish in a week (no more than 6oz of tuna)
check advisories about the safety of fish
no more than 12 ounces or 2 meals of fish in a week (no more than 6oz of tuna)
check advisories about the safety of fish
What makes lead useful?
dense malleable, long life spand, low melting point, corrosion resisten
what is the inorganic forms of lead
lead acetate or lead carbonate
what is the organic form of lead
tetraethyllead (TEL)
how can lead be absorbed?
GI tract
what percentact of lead do adults absorb compared to kids
10%/50%
where can lead be distributed in the body
blood, soft tissue (liver kidney) and bone
is there metabolism for inorganic laed?
no
is there metabolism for organic lead
undergoes dealkylation in the brain and liver
why are children susceptible to lead effects?
HAND TO MOUTH ACTIVITY
absporb lead from GI tract
bloor brain barrier
absporb lead from GI tract
bloor brain barrier
what were the lead exposures in the 20th century
leaded paint
leaded gasoline
lead smelters
other home products
leaded gasoline
lead smelters
other home products
where was a lead smelter located
butte, MT
lead was commonly used in what that got into the water supply?
pipes!
what kind of lead is used in gasoline
tetraethyl lead
what was the public heath intervention for lead in gasoline
remove Pb2+ from gasoline in the 1970s
decresed by 98% from 1970s to 1996 in emissions
decresed by 98% from 1970s to 1996 in emissions
What type of lead is used in lead peant?
lead acetate/lead carbonate
when was the removal of lead from paint by us law?
banned in the US in 1977
what is the current mass lead poisoning?
Dakar Senegal from battery recycling
what is a cognitive result of lead poisoning?
cognitive deficits as lower IQ scores (no threshold seen)
suppose that thalidomine instead of causing the birth of children with _______ ____ had instead reduced their ________ _______ by 10%
missing limbs, intellectual potential
what are the behavioral effects of lead?
increased aggression and delinquency
decreased attention
more likely to commit crime
decreased attention
more likely to commit crime
does chelation therapy reverse cognitive deficits of high lead blood levels?
NO it just lowers blood levels
the morris water maze showed
spatial learning and memory in rats (PROBE TEST)
rats with high lead levels shows higher ...
escape latency (time to platform discovery)
there is a disproportionate exposure of lead to..
inner city children/lower ses
why is lead still a public health problem
persists in the environment
disproportionate exposure
lack of threshold for neurological deficits
current methods for treatment are NOT effective on learning deficits
disproportionate exposure
lack of threshold for neurological deficits
current methods for treatment are NOT effective on learning deficits
About this deck
By: Lauren Burke
Created: 2011-10-19
Size: 39 flashcards
Views: 3
Created: 2011-10-19
Size: 39 flashcards
Views: 3
About StudyBlue
STUDYBLUE makes things that make you better at school.
Things like online flashcards with photos and audio.
Things like personalized quizzes and friendly reminders about when (and what) to study next.
Think of it as a digital backpack™: access to all of your study materials online and on your phone.
STUDYBLUE exists to make studying efficient and effective for every student, for free. Join us.
“I have used this website for three exams, and I see a huge difference in my test results.”
Naj
Naj