Pharmacology chapter 9 (Adrenergics)

Pharmacology 1 with 1 at Seton Hill College

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By: James Wu
Created: 2010-10-08
Size: 43 flashcards
Views: 116

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Name the class: alpha-Methyltyrosine

Inhibitor of catecholamine synthesis

Describe the mechanism of: alpha-Methyltyrosine

Inhibits tyrosine hydroxylase (rate-limiting enzyme in catecholamine biosynthesis pathway)

Name the class: Reserpine

Inhibitor of catecholamine storage

Describe the mechanism: Reserpine

inhibits catecholamine storage in vesicles, resulting in short-term increase in release of catecholamines from synaptic terminal but long-term depletion of available pool of catecholamines

List the serious adverse effects of: Reserpine

cardiac arrhythmia, GI hemorrhage, thrombocytopenia, dream anxiety disorder, impotence, psychotic depression

List some contraindications for: Reserpine

Active GI disease, depression, electorshock therapy, Renal failure

Name the class: Guanethidine, Guanadrel

Inhibitor of catecholamine storage

Describe the mechanism: Guanethidine, Guanadrel

inhibits catecholamine storage in vesicles, resulting in short-term increase in release of catecholamines from synaptic terminal but long-term depletion of available pool of catecholamines

List the serious adverse effects of: Guanethidine, Guanadrel

Kidney disease, apnea

List some contraindications for: Guanethidine, Guanadrel

MAOI therapy, heart failure, pheochromocytoma

Name the class: Amphetamine, Methylphenidate

Inhibitor of catecholamine storage

Describe the mechanism: Amphetamine, Methylphenidate

inhibits catecholamine storage in vesicles, resulting in short-term increase in release of catecholamines from synaptic terminal but long-term depletion of available pool of catecholamines

List the serious adverse effects of: Amphetamine, Methylphenidate

Hypertension, tachyarrhythmia, Gilles de la Tourette's syndrome, seizure, psychotic disorder with prolonged use

List some contraindications for: Amphetamine, Methylphenidate

Advanced cardiovascular disease, glaucoma, hyperthyroidism, MAOI therapy, severe hypertension

What are some clinical applications of: Amphetamine, Methylphenidate?

ADHD, narcolepsy (amphetamine only)

Name the class: Pseudoephedrine

Inhibitor of catecholamine storage

Describe the mechanism: Pseudoephedrine

inhibits catecholamine storage in vesicles, resulting in short-term increase in release of catecholamines from synaptic terminal but long-term depletion of available pool of catecholamines

List the serious adverse effects of: Pseudoephedrine

Atrial fibrillation, ventricular premature beats, Myocardial ischemia

List the contraindications for: Pseudoephedrine

Advanced cardiovascular disease, MAOI therapy, severe hypertension

Name the class: Cocaine, imipramine, amitriptyline

Inhibitor of catecholamine reuptake

Name the class: Phenelzine, iproniazid

Monoamine oxidase (MAO) Inhibitor

Describe the mechanism of: Phenelzine, iproniazid

Inhibits MAO, increases catecholamine levels by blocking catecholamine degradation

Name the class: Methoxamine

a1-adrenergic agonist

Describe the mechanism of: Methoxamine

Activates a1-adrenergic receptors to increase peripheral vascular resistance (increases contraction of smooth muscle too)

List the serious adverse effects of: Methoxamine

Bradycardia (vagal reflex), ventricular ectopic beat

List the contraindication for: Methoxamine

Severe hypertension

Name the class: Phenylephrine

a1-adrenergic agonist

Describe the mechanism: Phenylephrine

Activates a1-adrenergic receptors to increase peripheral vascular resistance (increases contraction of smooth muscle too)

List the serious adverse effects: Phenylephrine

Cardiac arrhythmia, hypertension

List the contraindications for: Phenylephrine

Narrow-angle glaucoma, severe hypertension or tachycardia

Name the clinical applications for the a1-adrenergic agonists

Hypotension, shock

Name the class: Clonidine

a2-adrenergic agonist

Deescribe the mechanism for: Clonidine

activates central a2-adrenergic receptors and inhibits sympathetic outflow from CNS (promotes decrease in norepinephrine, decreased insulin release, decrease smooth muscle contraction)

What are some clinical applications for: Clonidine?

Hypertension, opiod withdrawal, cancer pain

List hte serious adverse effects of Clonidine

Bradycardia, heart failure

List a clinical application for a-methyldopa

Drug of choice for treatment of hypertension in pregnancy

Name the class: Isoproterenol, dobutamine, albuterol

Beta-adrenergic agonist

Name the class: Phenoxybenzmine, phentolamine

alpha-adrenergic Antagonist

Name the general class: Propranolol, labetalol, metoprolol, atenolol

Beta-adrenergic antagonist

Name the specific class of: Propranolol

Nonselective B1 and B2 antagonist

Name the specific class of: Labetalol

A1, B1, and B2 blocker

Name the specific class of Metoprolol and atenolol

B1-selective antagonist

List the serious adverse effects of Beta-adrenergic antagonists

Bronchospasm, AV block, bradyarrhythmia

About this deck

By: James Wu
Created: 2010-10-08
Size: 43 flashcards
Views: 116

About StudyBlue

“I have been getting MUCH better grades on all my tests for school. Flash cards, notes, and quizzes are great on here. Thanks!”
Kathy