Diseases of the Skin 4-27

StudyBlue printing of Diseases of the Skin 4-27 html, body, div, span, applet, object, iframe, h1, h2, h3, h4, h5, h6, p, blockquote, pre, a, abbr, acronym, address, big, cite, code, del, dfn, em, font, img, ins, kbd, q, s, samp, small, strike, strong, sub, sup, tt, var, b, u, i, center, fieldset, form, label, legend, table, caption, tbody, tfoot, thead, tr, th, td { margin: 0; padding: 0; border: 0; outline: 0; font-size: 100%; background: transparent; } body { line-height: 1; } blockquote, q { quotes: none; } blockquote:before, blockquote:after, q:before, q:after { content: ''; content: none; } /* remember to define focus styles! */ :focus { outline: 0; } /* remember to highlight inserts somehow! */ ins { text-decoration: none; } del { text-decoration: line-through; } /* tables still need 'cellspacing="0"' in the markup */ table { border-collapse: collapse; border-spacing: 0; } /* end RESET */ .header { min-width:800px; } .logo { padding:6px 20px 2px 20px; margin:0; font-size:25px; font-weight:bold; color:#808285; position:relative; border-bottom: 1px solid #c5c5c5; } .logo-blue { color:#70adc4; } .logo-desc { font-weight:normal; font-size:19px; color:#cccccc; margin-top:50px; position:absolute; display: none; } .back-button { position:absolute; top:20px; right:20px; font-size:13px; line-height:25px; color:rgb(0,175,225); font-weight:normal; } .back-button a { color:rgb(0,175,225); } .instructions { padding:0; margin:0; width:100%; position:relative; color:rgb(100,100,100); } .step-holder { border-left:1px solid #ededed; margin-left:20px; } .steps { padding:15px 0; float:left; width:24%; border-right:1px solid #ededed; text-align:center; } .steps-01 { } .steps-02 { } .steps-03 { } .steps-04 { } .label { padding:5px 10px; } .print-button { } .print-button a { background-color:rgb(0,175,225); color:white; line-height: 19px; padding:9px 8px 5px 30px; font-size:14px; text-decoration:none; background-image: url(images/printer.png); background-repeat: no-repeat; background-position: 7px 50%; -moz-border-radius: 5px; -webkit-border-radius: 5px; } .print-button a:hover { background-color:black; } .theNote .content { width: 8.0in !important; margin: 5px auto; padding:20px; background-color:white; } .theNote .header { border-bottom: 1px dashed #C8C8C8; font-size: 17px; padding: 0 0 10px; line-height: 19px; color: #00ADE1; min-width:500px; } .theNote .body { font-size: 14px; line-height: 19px; padding: 10px 0; } .theNote{ padding:6px 0; clear:both; background-color: rgb(200,200,200); } .theNote h3{ color: rgb(100,100,100); } .theNote h1, .theNote h3{ background-color:white; padding:2px 20px; width:8.0in !important; margin: 0 auto; font-size: 15px; } .theNote h1{ padding-top: 10px; font-size: 15px; } .theNote h1:first-child{ font-size: 20px; } .theNote h3 { font-size: 14px; font-weight: normal; } #options { border: 3px double #ccc; padding: 5px 12px; margin: 10px 50px 10px 20px; float: left; } #info { border-top: 1px solid #ccc; padding-top: 5px; font-style: italic; } li { margin: 5px 10px 5px 25px; } ul li { list-style: disc; } ol li { list-style: decimal; } img { border: 0; } table { clear: both; width: 100%; border: 1px solid #c5c5c5; border-width: 1px 0; margin: 0; page-break-after: always; } table#page { page-break-after: auto; } td { text-align: center; font-size: 12px; border-bottom: 1px dashed #c5c5c5; height: 1.75in; width: 50%; padding-left: 15px; } .leftside { border-right: 1px solid #cccccc; padding: 0 15px 0 0; } .bottom td { border-bottom: none; } .clearfix { clear:both; line-height:1px; height:1px; } img { max-width:80%; max-height:150px; margin:20px; } @media print {.header { display: none; } .content .header{ display:inherit; } table { border: 1px dashed #bbb; border-width: 1px 0; } .theNote{ background-color:white; } } Diseases of the Skin Skin Bacterial types of diseases examples pathogenesis Tx Viral ibid (same as above) Skin covers body protects 1st line of defense unhospitable environment acidity- fatty acids dry being bombarded by radiation physical barrier can be broken Flora protective function competes with pathogenesis resident Staphylococcus epidermidis Gram positive 90% of flora resident bacteria-can cause infection Bacterial diseases Furunculosis boils furnucles S. aureus (causative agent) enters hair follicle infects subcutaneous tissue develops into abscess (pus) virulence factor Protein A binds to F c of Ab prevents binding of Ab to F c R (receptor) on macrophages allows spread Tx antibiotics tests must be ran, person may die before Tx may begin Scalded Skin Syndrome Ritter's disease Staph. fatal toxin mediated infants, adults, children Sx redness malaise irritability fever wrinkled skin blisters swell burst painful-tender to touch sand paper like skin 5% of Staph. Pathogenesis exfoliants virulence factor that bind to "glue" that holds skin together Esterase (virulence factor site) can kill patient makes skin come off Tx isolation PPE methicillin debridement (cut out infected parts) Impetigo outer skin layers S. aureus or Streptococcus pyogenes ( fear!!) responsible for most deaths Pathogenesis starts out with a scratch Virulence factors Proteases (mess with protein) Nucleases (go after nucleic acid) Hyaluronidase (destroys hyaluronic acid (keeps tissue together)) M Protein (interferes with phagocytosis) most prevalent in children that live in humid places Tx Penicillin (Pn) Erythromycin (Em) Pv personal cleanliness Rocky Mountain Spotted Fever Sx headache muscle and joint pain fever faint rash palms wrists ankles soles of feet spread to arms, legs, rest of body becomes raised (swelled) becomes hemorrhagic bleeding may come from mouth and nose may spread to heart and kidney-can cause shock Rickettsia rickettsii obligate-intracellular Gram negative non-motile coccobacilli (oval) Pathogenesis tick bite blood vessel cells endocytosis inflammation at sites where bacteria entered cells clotting necrosis (tissue death) spread from skin to organs endotoxins induce shock intravascular coaugulation zoonotic disease Pv avoid ticks Tx Tetracyclin (Tc) Chloramphenicol (Cm) 5% death rate if treated right Lyme Disease spirochete Lyme, CT causative agent - Borrelia burgdorferi 11-25 um in length Sx erythema chronicum migrans (skin rash) 1 heart and nervous system malfunction 2 arthritis 3 Pathogenesis tick bite tissue inflammation-rash 1- IS down 2 and 3- IS up Tx doxycycline erthyromycin (Em) Ampicillin (Amp) Ceftriaxane Viral Diseases Chicken Pox Varicella Zoster (virus) Sx Macules Papules Vesicles Pustulus breaks (release virus) crust pruitic (itchy) 2 0 infections Shingles- old people chicken pox