Endocrine Disorders

Pharmacy Practice 3312 with Toor at Lipscomb University

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By: Joel Daniel
Created: 2011-11-03
Size: 28 flashcards
Views: 5

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Requirements for Dx of DM

Sx plus random BG >=200mg/dl

Fasting BG >=126mg/dl

2-hr Post-Prandial OGTT >=200

Age, Onset, and Acute Complication with T1DM

age<30yo

Abrupt

Diabetic Ketoacidosis

Age, Onset, and Acute Complication with T2DM

>30yo

Gradual

Hyperosmolar Hyperglycemic State

S/Sx associated with Hyperglycemia

Signs

Elevated BG/A1C

Urine Ketones

Urine Glucose

Polyuria/Polydipsia

Polyphagia

Weight Changes

Blurred Vision

Etc.

Autonomic S/Sx associated with Hypoglycemia

Tremor/shakiness

Anxiety

Palpitations/Tachycardia

Sweating

Hunger

Neuroglycopenic S/Sx associated with Hypoglycemia

Weak/Fatigued

Behavioral changes

Confusion

Natural Products and Dietary Supplements for the Tx of DM

Alpha-Lipoic Acid (ALA)

American Ginseng

Cinnamon

Bitter Melon

Fenugreek

Chromium

Proposed Indications for Iodine

Goiter

Hyperthyroidism

Radiation Exposure

Endocrine Indication with DHEA

Adrenal Insufficiency

Dosing Key Points with ALA

Administer on an empty stomach

Separate by 2-3 hours from antacids/minerals

AEs of ALA

Nausea

Allergic Rash

DI/Caution with ALA

Glucose Lowering Agents (hypoglycemia)

Levothyroxine (inhibits conversion to T₄)

What is something to look for when selecting an American Ginseng product for DM

Make sure it is AMERICAN

Do not confuse with Asian or Siberian Ginseng

Dosing Note with American Ginseng

Take within 2 hours of a meal to avoid hypoglycemia

AEs of American Ginseng

Increased/Decreased BP

Increased/Decreased GB

GI disturbances

Insomnia and agitation

CI with American Ginseng

Schizophrenia or Psychotropic Agents

DI with American Ginseng

Warfarin

Psychotropic Agents

Dosing note of Cinnamon for DM usage

1-6 g qd in divided doses

Potential DI with Cinnamon

Anticoagulants

Contains coumarins, though this has not really been much of an issue

MOA of Bitter Melon

May slow progression of microalbuminuria and diabetic nephropathy

Safety Issues with Bitter Melon

GI Complications

HA (with seeds)

Hypoglycemia

Avoid in G6PD Deficiency

Caution with Fenugreek

May exacerbate asthma

Maple syrup syndrome

DI with Fenugreek

Anticoagulants/Antiplatelets (contains coumarins)

Antidiabetics (hypoglycemic)

AEs of Chromium

Cognitive Disturbances

Mood Disturbances

DI with Chromium

Antidiabetics

Levothyroxin (decreased absorption)

Zinc (may decrease absorption of both)

Dosing notes with Iodine

Should be under medical supervision

Limit to 14 days of therapy

AEs with Iodine

N/D

Abdominal pain

Metallic Taste

DI with Iodine

ACE-I/ARB

K-sparing diuretics

About this deck

By: Joel Daniel
Created: 2011-11-03
Size: 28 flashcards
Views: 5

About StudyBlue

“Simply amazing. The flash cards are smooth, there are many different types of studying tools, and there is a great search engine. I praise you on the awesomeness.”
Dennis