Gram Negatives #2
Microbiology Medical Microbiology with Goin at University of Pittsburgh - Pittsburgh
About this deck
By: Joshua Weis
Created: 2011-03-05
Size: 63 flashcards
Views: 4
Created: 2011-03-05
Size: 63 flashcards
Views: 4
About StudyBlue
STUDYBLUE makes things that make you better at school.
Things like online flashcards with photos and audio.
Things like personalized quizzes and friendly reminders about when (and what) to study next.
Think of it as a digital backpack™: access to all of your study materials online and on your phone.
STUDYBLUE exists to make studying efficient and effective for every student, for free. Join us.
“Simply amazing. The flash cards are smooth, there are many different types of studying tools, and there is a great search engine. I praise you on the awesomeness.”
Dennis
Dennis
Sign up (free) to study this.
Bacteroides fragilis - BASIC FEATURES MENTIONED
strict anerobe
Bacteroides fragilis - DISEASE(s)
Peritonitis leading to abcess formation
Bacteroides fragilis - NOTABLE FEATURES
colon - most prevelant bacterium
Has capsule
Porphyromonas gingivalis - BASIC FEATURES MENTIONED
strict anerobe
Porphyromonas gingivalis - DISEASE(s)
Gingivitis
Porphyromonas gingivalis - NOTABLE FEATURES
oral infection
Prevotella bivia - BASIC FEATURES MENTIONED
strict anerobe
Prevotella bivia - DISEASE(s)
Pelvic inflammatory disease
Prevotella bivia - NOTABLE FEATURES
colonizes vagina
Prevotella melaninogenica - BASIC FEATURES MENTIONED
strict anerobe
Prevotella melaninogenica - DISEASE(s)
Respiratory tract infections
Prevotella melaninogenica - NOTABLE FEATURES
has capsule
Enterobacter cloacae - DISEASE(s)
Hospital-acquired pneumonia
Enterobacter cloacae - NOTABLE FEATURES
None
Yersinia pestis - BASIC FEATURES MENTIONED
encapsulated (AA, not sugars)
Yersinia pestis - DISEASE(s)
Bubonic plague (bioterror threat)
Yersinia pestis - NOTABLE FEATURES
Flea bites or inhalation
Yersinia enterocolytica - BASIC FEATURES MENTIONED
Intracellular (faculative) - mostly outside
Yersinia enterocolytica - DISEASE(s)
Yersinosis - fever, cramps and diarrhea
Yersinia enterocolytica - NOTABLE FEATURES
ingestion (zippered entry into M cells)
invasin binds beta-integrin to enter colonic subepithelium and reproduce extracellularly.
Salmonella typhi - BASIC FEATURES MENTIONED
Intracellular (faculative)
encapsulated
motile
makes H2S
Salmonella typhi - DISEASE(s)
Typhoid - fever and malaise
then delerium
then GI damage
Salmonella typhi - NOTABLE FEATURES
Ingestion (cell entry by membrane ruffling)
invasive spread inside macrohages
spreads through body and can return to sensitized GI tract via bile
TREATMENT: cipro/whatever, if that fails, cystectomy
Salmonella spp. - BASIC FEATURES MENTIONED
Intracellular (faculative)
encapsulated
motile
makes H2S
Salmonella spp. - DISEASE(s)
Salmenelosis - gastroenteritis
Salmonella spp. - NOTABLE FEATURES
Ingestion (cell entry by membrane ruffling of any cell in illeum)
enters subepithelium (can survive in macrophages )
PhoP/PhoQ is a two component regulatory system that switches expression pattern between intracellular and extracellular environment
Shigella dysenteriae - BASIC FEATURES MENTIONED
Intracellular (faculative)
encapsulated,
Shigella dysenteriae - DISEASE(s)
Shigellosis - gastroenteritis by shiga toxin
water bourne, fecal/oral
Shigella dysenteriae - NOTABLE FEATURES
Ingestion
cell entry by membrane ruffling of M cells in colon (invasin is on a plasmid)
IcsA protein steals host actin for motility inside and between cells
stays in epithelium and secretes shiga toxin (inactivates ribosomes)
Klebsiella pneumoniae - BASIC FEATURES MENTIONED
encapsulated
Klebsiella pneumoniae - DISEASE(s)
Hospital-acquired pneumonia
UTI
ankylosing spondylitis by molec. Mimicry
Klebsiella pneumoniae - NOTABLE FEATURES
hard to phagocytize
has beta lactamase (against ampicillin and possibly any other beta lactam)
Escherichia coli - BASIC FEATURES MENTIONED
lactose(+)
Escherichia coli - DISEASE(s)
Gastroenteritis
UTI and cystitis
bacteremia (water bourne)
Escherichia coli - NOTABLE FEATURES
Becoming resistant to Trimethoprim/Sulfonamides and piperacillin (beta-lactamases)
can use lactose, so turns MacConkey pink
EIEC (enteroinvasive) - BASIC FEATURES MENTIONED
Intracellular (faculative)
EIEC (enteroinvasive) - DISEASE(s)
Gastroenteritis (similar to low-tech shigella)
EIEC (enteroinvasive) - NOTABLE FEATURES
Invade enterocytes and multiply intracellularly.
EPEC (enteropathogenic) - BASIC FEATURES MENTIONED
extracellular (on pedastal)
EPEC (enteropathogenic) - DISEASE(s)
Gastroenteritis
EPEC (enteropathogenic) - NOTABLE FEATURES
binds enterocytes and directly injects transcription factors and the adhesin TIR (through type III secretion system - direct across both cell membranes) forms "pedastal" for bacteria
EHEC (enterohemorhagic) - BASIC FEATURES MENTIONED
extracellular (on pedastal)
EHEC (enterohemorhagic) - DISEASE(s)
Gastroenteritis, (hemmhoragic, with kidney damage)
no antibiotics with renal infection
EHEC (enterohemorhagic) - NOTABLE FEATURES
same as EPEC but produces shiga toxin, which inhibits ribosomes
absorbed by gut and also damages kidneys
can have zoonotic reservoirs
ETEC (enterotoxic) - DISEASE(s)
traveler's diarhhea ("Montezuma's revenge")
ETEC (enterotoxic) - NOTABLE FEATURES
CFA pilli allow colonization in small intestine
secretes heat labile enterotoxin like cholera toxin, ups cAMP and caues diarrhea (and heat-stable enterotoxin, which raises cGMP)
EAEC (enteroaggregative) - DISEASE(s)
Gastroenteritis (mild, chronic)
EAEC (enteroaggregative) - NOTABLE FEATURES
Adhere in aggregates
stimulate mucous production to make biofilm => forms toxins similar to ETEC
UPEC (uropathogenic) - DISEASE(s)
UTI
UPEC (uropathogenic) - NOTABLE FEATURES
P-pilli attack to urogenital tract and kidney
K1 strains - BASIC FEATURES MENTIONED
encapsulated
K1 strains - DISEASE(s)
meningitis
K1 strains - NOTABLE FEATURES
sialic acid capsule mimics host and is antiphagocytic
Borrelia burgdorferi - BASIC FEATURES MENTIONED
Obligate intracellular
Borrelia burgdorferi - DISEASE(s)
Lyme disease
1. bullseye rash (erethema migrans)
2. eye and nervous sys. inflammation (variable)
3. chronic: arthritis, demyelination, fatigue
Borrelia burgdorferi - NOTABLE FEATURES
Tick in east and midwest is vector (48 hour attachment, esp. at nymph phase)
very "sticky", so colonizes easily
diagnose w/ ELISA and western blot. (much like HIV)
Treponema pallidum - BASIC FEATURES MENTIONED
Obligate intracellular
Treponema pallidum - DISEASE(s)
Syphilis
1. chancre
2. small dark-spotted rash and malaise
3. gummas, neurosyphilis, cardiovascular
Treponema pallidum - NOTABLE FEATURES
Microaerophile
transfer from mother to child
baby has sunburn-like rash, hepatosplenomegaly and poor bones.
diagnose w/ RPR (rapid plasma reagent)
About this deck
By: Joshua Weis
Created: 2011-03-05
Size: 63 flashcards
Views: 4
Created: 2011-03-05
Size: 63 flashcards
Views: 4
About StudyBlue
STUDYBLUE makes things that make you better at school.
Things like online flashcards with photos and audio.
Things like personalized quizzes and friendly reminders about when (and what) to study next.
Think of it as a digital backpack™: access to all of your study materials online and on your phone.
STUDYBLUE exists to make studying efficient and effective for every student, for free. Join us.
“Simply amazing. The flash cards are smooth, there are many different types of studying tools, and there is a great search engine. I praise you on the awesomeness.”
Dennis
Dennis