IBD Sulfa-Free Mesalamine Products
About this deck
By: Celeste Karpow
Created: 2012-02-19
Size: 9 flashcards
Views: 4
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- Delayed Release tablets
- Terminal ileum/ colon
- Mild-Mod UC induction & maintenance of remission
- 5-ASA coated w/ pH sensitive coating—Eudragit-S
- NOT prodrug
- Delayed & Extended Release tablets
- Colon
- Active Mild-Mod UC
- Outer coating dissolves at pH 7 & lipophilic matrix→ triple coating⇒ SLOW dissolution
- QD PO dosing
- Ctrl'd-release caps
- Sm Bowel (Duod, jej, il) & colon
- Mesalamine Microspheres
- Moisture activated, disintegrate in stomach
- → CR microspheres disperse into sm bowel & colon
- Mild-Mod UC induction of remission→ 6-8 wks duration
- NOT maintenance of UC OR CD
- NOT prodrug
- Rectal Enema
- 5-ASA
- Rectum, Sigmoid colon, & up to splenic flexure
- Proctitis, Distal Colitis, Left-sided colitis ↑ splenic flexure
- 5-ASA
- Rectum
- Active UC involving rectum only (proctitis)
- Balsalazide (pro-drug)
- Delivered intact to COLON & cleaved by bacterial azo-reduction to release mesalanine
- COLON
- Mild-Mod Active UC
- Olsalazine (pro-drug)
- 2 mesalanine joined by diazo bond in a capsule
- COLON
- Maintenance of remission in UC intol to sulfasalazine, NOT acute UC
Non-severe effects:
- Diarrhea, Headache, N/V, abdominal pain, dyspepsia, rash
- 80% sulfasalazine intol pts can tolerate 5-ASA, 20% have sim effects
- AVOID in pts allergic to ASPIRIN
- May take wks-mths to work at appropriate doses
- Treatment Options: Oral Aminosalicylates, topical mesalamine, or topical steroids
- Topical mesalamine agents are superior to topical steroids OR oral aminosalicylates
- ⇒ Combo of oral & topical aminosalicylates are more effective than either alone.
About this deck
By: Celeste Karpow
Created: 2012-02-19
Size: 9 flashcards
Views: 4
About StudyBlue
STUDYBLUE makes things that make you better at school.
Things like
online flashcards with photos and audio.
Things like personalized quizzes and friendly reminders about when (and what) to study next.
Think of it as a digital backpack™: access to all of your study materials online and on your phone.
STUDYBLUE exists to make studying efficient and effective for every student, for free.
Join us.
“I have been getting MUCH better grades on all my tests for school. Flash cards, notes, and quizzes are great on here. Thanks!”
Kathy
