Lecture April 12

Cell Biology And Neuroscience 356 with Golfetti at Rutgers University - New Brunswick/Piscataway

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By: Christina Peteraf
Created: 2011-04-12
Size: 15 flashcards
Views: 104

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What ion is responsible for depolarization?

Sodium (influx)

What ion is responsible for repolarization?

Potassium (efflux)

What is the refractory period?

AP cannot happen, cell is hyperpolarized

What is an electrical potential?

difference in concentration of charged particles between different parts of the cell

What is the resting membrane potential?

-70 mV

What is the distribution of ions inside and outside cell?

Inside: more potassium (cation)

Outside: more Sodium (cation)

More Cl- outside of the cell

What is the early theory of membrane potential?

Membrane only permeable to K+

based on chemical gradient- efflux of K+

generated electrical gradient opposes chemical force- must reach equilibrium potential (no net movement across membrane)

What gradient drives Potassium outside of the cell?

Chemical gradient (much more K+ inside cell)

What energy-costly mechanism is constantly at work to upkeep proper chemical gradients of the cell

sodium-potassium pump (requires ATP)

how many sodium ions are pumped out for each potassium ion pumped in?

1.5

(pumps 3 Na+ for every 2 K+ ions)

Nernst equilibrium potential

electrical potential that would exactly balance chemical potential due to concentration gradient:

E(ion)= (RT/zF) x ln Co/Ci

Flux

determined by both force and permeability

Flux = Permeability x Force = P x (Vm - Eion)

Purpose of Goldman Equation

calculates Vm when more than one ion species is permeable

Vm is closest to the equilibrium potential for which ion?

potassium

What produces hyperpolarization?

negative overshoot due to potassium efflux

About this deck

By: Christina Peteraf
Created: 2011-04-12
Size: 15 flashcards
Views: 104

About StudyBlue

“I have been getting MUCH better grades on all my tests for school. Flash cards, notes, and quizzes are great on here. Thanks!”
Kathy