Lecture Notes for Oct 8, 2008
Biochemistry 405 with Brockerhoff at University of Washington - Seattle Campus
About this deck
By: Kim Jasmer
Textbook:
Fundamentals of Biochemistry: Life at the Molecular Level
Created: 2008-10-31
Size: 16 flashcards
Views: 6
Textbook:
Fundamentals of Biochemistry: Life at the Molecular LevelCreated: 2008-10-31
Size: 16 flashcards
Views: 6
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Oxygen binding curve for
(2 answers)
(2 answers)
- hemoglobin loses oxygen when not enough
- Myoglobin takes really low oxygen concentration to lose
Oxy Hb
(2 answers)
(2 answers)
- planar
- smaller iron atom
Altitude
(3 answers)
(3 answers)
- BPG
- pick up less in lungs but deliver more in muscle
- with BPG we deliver way more oxygen than would have at altitude
Hemocyanin
(3 answers)
(3 answers)
- the ocygen binding protein in blue blood of mollusks
- does not contain any heme
- contains copper molecules
sequential model
(1 answer)
(1 answer)
- neighboring subunits change conformation as well
red blood cells are not flexible
(1 answer)
(1 answer)
- capillaries get blocked
bad version has valine which fits beautifully in hydrophobic pocket
(1 answer)
(1 answer)
- can form fibers of sickle cell hemoglobin
Oxygen Binding curve of
(1 answer)
(1 answer)
- association constant is 1/K
Allosteric Proteins
(3 answers)
(3 answers)
- the binding of one ligand at one site affects the binding of another ligand at another site
- symmetric model
- sequential model
Myoglobin
(2 answers)
(2 answers)
- amino acids named by helix
- Oxygen Binding curve of
Deoxy Hb
(2 answers)
(2 answers)
- bend
- iron is larger
Myoglobin takes really low oxygen concentration to lose
(1 answer)
(1 answer)
- bad oxygen delivery
in oxyHemoglobin the cavity in which BPG binds closes up
(2 answers)
(2 answers)
- how?
- binding of oxygen changes a little bit in tertiary structure which causes a big change in subunits with respect to eachother
symmetric model
(1 answer)
(1 answer)
- ligand can bind to both conformations
Hemoglobin
(9 answers)
(9 answers)
- 2 alpha subunits
- 2 beta subunits
- in oxyHemoglobin the cavity in which BPG binds closes up
- Deoxy Hb
- Oxy Hb
- Oxygen binding curve for
- Salt bridge gets ruptured in oxy state of Hemoglobin
- at low pH, oxygen affinity is lower
- In oxy state the hole is too small to fit BPG
Sickle Cell Anemia
(4 answers)
(4 answers)
- red blood cells are not flexible
- Hemoglobin with only one change in an amino acid
- bad version has valine which fits beautifully in hydrophobic pocket
- Sickle cell hemoglobin (when mixed with normal) protect against Malaria
About this deck
By: Kim Jasmer
Textbook: Fundamentals of Biochemistry: Life at the Molecular Level
Created: 2008-10-31
Size: 16 flashcards
Views: 6
Textbook:
Fundamentals of Biochemistry: Life at the Molecular LevelCreated: 2008-10-31
Size: 16 flashcards
Views: 6
About StudyBlue
STUDYBLUE makes things that make you better at school.
Things like online flashcards with photos and audio.
Things like personalized quizzes and friendly reminders about when (and what) to study next.
Think of it as a digital backpack™: access to all of your study materials online and on your phone.
STUDYBLUE exists to make studying efficient and effective for every student, for free. Join us.
“I have used this website for three exams, and I see a huge difference in my test results.”
Naj
Naj