What are 3 alpha-herpesviruses?
1.) HSV 1
2.) HSV 2
3.) Varicella-zoster virus (VZV)
VZV causes systemic multi-organ disease-which may be due to its capacity to infect and be transported by circulating leukocytes
1.) Acute disease (facial or genital lesions, stomatitis, or keratitis); localized
4.) Recurrent disease (cold sores, fever blisters, keratitis, or genital lesions)
1.) Acute disease (chicken pox)
4.) Reactivation disease (zoster or shingles)
--its an analog of guanosine that becomes phosphorylated by herpesvirus enzymes and incorporates them into viral DNA as a chain-terminating nucleotide
--has valine sidechain
What kind of virus are Alphaherpesviruses?