Nicotinic Antagonists

Pharmacology 350 with Cobbett at Michigan State University

About this deck

By: Jessica Wummel
Created: 2010-10-13
Size: 14 flashcards
Views: 5

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Autonomic ganglia

N_N

variable autonomic effects

Neruromuscular junctino

N_M

"muscle weakness"

competitive blocker

simple antagonist
binds to N receptor
prevents ACh binding to receptor

blocks ACh effect

competive blockers for N_M

gallamine

atracurium

tubocurarine (curare)

competive blockers for N_N

trimethaphan

mecamylamine

Non competive blockers

binds to N receptor
mimics ACh
desensitizes receptor

blocks ACh effect

non competitive blocker for N_M

succinylcholine

non competitive blcoker for N_N

nicotine

NMJ blockers - uses

surgery
orthopedic procedures (resetting breaks)
ventilator control
tracheal inubation
adjunct to ECT
muscular convulsions

competitive antagonist reversal

add ChEase

non competitive agonist reversal

time

order of innervation

NMJ blockers

affect site of highest innervation first

face
limbs
trunk
diaphragm

Autonomic Ganglion blockers - uses

hypertensive crises

spike of unprovoked high BP

induction of hypotension in surgery

to reduce bleeding

Trimethaphan - mechanism of action

decrease of both PNS and SNS input to heart

no net effect

blood vessels only innervated by SNS

↓ input to arterioles

vasodilation, ↓ blood pressure

↓ input to small veins

↓blood return to heart
↓co, ↓BP, ↓ tissue perfusion, ↓bleeding

About this deck

By: Jessica Wummel
Created: 2010-10-13
Size: 14 flashcards
Views: 5

About StudyBlue

“I have used this website for three exams, and I see a huge difference in my test results.”
Naj