Pharm- GI
Medical Anatomy And Physiology 1 with Me at University of Louisville
About this deck
By: Melissa Huscusson
Created: 2011-05-19
Size: 29 flashcards
Views: 5
Created: 2011-05-19
Size: 29 flashcards
Views: 5
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Cimetidine
H2 blocker
Ranitidine
H2 blocker
Famotidine
H2 blocker
Nizatidine
H2 blocker
MOA of H2 blockers
Decreased H+ secretion by parietal cells
Which H2 blocker is a CYP-450 inhibitor?
Cimetidine
Cimetidine side effects?
Anti-androgenic effects--> prolactin release, gynecomastia, impotence, decreased libido
Can cross BBB--> confusion, dizziness, HA
Crosses placenta
Decreased renal excretion of creatinine
Omeprazole
PPI
Lansoprazole
PPI
Proton pump inhibitor MOA
Irreversibly inhibits H+/K+ ATPase in stomach parietal cells
Triple therapy of H. pylori
- Metronidazole
- Amoxicillin (or Tetracycline)
- Bismuth
Bismuth, Sucralfate MOA
Binds to ulcer base, providing physical protection and allow HCO3- secretion to reestablish pH gradient in the mucous layer
Misoprostol USE
- Prevention of NSAID-induced peptic ulcers
- Maintenance of PDA
- Induction of labor (also an abortifacient)
Pirenzepine, Propantheline MOA
Muscarinic antagonists
- Blocks M1 receptors on ECL cells (decreased histamine secretion)
- Blocks M3 receptors on parietal cells (decreased H+ secretion)
**Tx of peptic ulcers but rarely used
Drug of choice for Tx of carcinoid syndrome?
Octreotide
Drug of choice for VIPom?
Octreotide
Octreotide MOA
Somatostatin analog
Infliximab
Monoclonal antibody to TNF
Infliximab use
Crohn's
RA
Patient presents w/ seizures, proximal muscle weakness, and constipation.
Aluminum hydroxide antacid overuse.
Can also cause osteodysrophy
Patient presents w/ diarrhea, decreased reflexes, and hypotension.
Magnesium hydroxide antacid overuse.
Can lead to cardiac arrest
Common SE of all antacids?
Hypokalemia
Sulfasalazine MOA
Combination of sulfapyridine (antibacterial) and 5-aminosalicylic acid (anti-inflammatory)
Activated by colonic bacteria
Sulfasalazine USE
Ulcerative colitis
Crohn's
Sulfasalazine TOX
Reversible oligospermia
Ondansetron MOA
5-HT3 antagonist
Central- acting emetic
DOC for post-op and post-chemo N/V
ondansetron
Metoclopramide MOA
D2 receptor antagonist--> increased resting tone, contractility, LES tone, motlity
DOC for Diabetic and post-surgery gastroparesis
Metoclopramide
About this deck
By: Melissa Huscusson
Created: 2011-05-19
Size: 29 flashcards
Views: 5
Created: 2011-05-19
Size: 29 flashcards
Views: 5
About StudyBlue
STUDYBLUE makes things that make you better at school.
Things like online flashcards with photos and audio.
Things like personalized quizzes and friendly reminders about when (and what) to study next.
Think of it as a digital backpack™: access to all of your study materials online and on your phone.
STUDYBLUE exists to make studying efficient and effective for every student, for free. Join us.
“I have used this website for three exams, and I see a huge difference in my test results.”
Naj
Naj