Quiz 1
Molecular Biology 410 with Konkel at Washington State University - Pullman campus
About this deck
By: Andrew McCanna
Created: 2012-01-18
Size: 17 flashcards
Views: 5
Created: 2012-01-18
Size: 17 flashcards
Views: 5
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A cytoplasmic membrane contains....
phospholipid bilayer, a sidedness to it (coming from complex phospho. and proteins) and a mosaic
the incorrect aspect of the cytoplasmic membrane given in class was....
lack of patchyness of proteins, lack of rafts.
phospholipid bilayer contains...
2 fatty acid chains with hydrophillic and hydrophobic ends, with hydrophillic ends sticking out.
Types of FA chains
saturated: fully hydrogenated: CH3ch2ch2ch2ch3
Mono-unsaturated (one dbl bond): ch3ch2ch2chchch2ch3
Poly-unsaturated (2+dbl bond): Ch3ch2chchch2chchch3
Can be cis or trans (cis better)
Mono-unsaturated (one dbl bond): ch3ch2ch2chchch2ch3
Poly-unsaturated (2+dbl bond): Ch3ch2chchch2chchch3
Can be cis or trans (cis better)
3 types of lipids we talked about
simple lipid, phospholipid, complex phospholipid
simple lipid components
Glycerol backbone with 3 FA tails ending in methyl groups. Cis is better than trans for simple lipids. Many types of simple lipid FA chains
phospholipid
glycerol backbone with 2 FA's and a phosphate
Complex phospholipid
glycerol backbone with 2 FA, phosphate, and polar head grp coming off the phosphate
Complex phospholipids are a common target for antibacterial agents b/c...
the phospholipids found in eukaryotes is different than those found in bateria.
3 types of protein sidedness and function.
inner membrane: energy, transport, DNA binding proteins
transmembrane(both leaflets): energy, nutrients, electron transport chain
outer: flagellar activity, cell wall synthesis
transmembrane(both leaflets): energy, nutrients, electron transport chain
outer: flagellar activity, cell wall synthesis
strategies for bacteria gettign iron:
important b/c used in electron transport chain
1. Kill epithelial cells using toxin (RBC for hemoglobin or muscle cells for myoglobin
2. produce iron transport proteins.
1. Kill epithelial cells using toxin (RBC for hemoglobin or muscle cells for myoglobin
2. produce iron transport proteins.
Gram + cell wall
Peptidoglycan: Teichoic acid(occasionally)---NAG----NAM---(1)L-Ala---(2)D-Glu---(3)L-Lys---(4)D-Ala---[D-Ala][only present durign synth.]
NAG---NAM is beta1,4 glycosidic linkage
G+ is 100% crosslinked [4-->3], using indirect linkages ( w/ Gly)
NAG---NAM is beta1,4 glycosidic linkage
G+ is 100% crosslinked [4-->3], using indirect linkages ( w/ Gly)
Gram - Cell wall
(no teichoic) NAG--NAM--L-Ala---D-Glu---DAP---D-Ala
-Direct link (not indirect)
Has initial bilayer, peptidoglycan, then another bilayer.
2nd bilayer has LPS on it.
-Direct link (not indirect)
Has initial bilayer, peptidoglycan, then another bilayer.
2nd bilayer has LPS on it.
lipoteichoic acid vs teichoic acid
lipoteichoic acid interact with cell membrane.
teichoic acid interact with cell wall. attach to peptidoglycan, stick out with a degree of variability, causing different immune response, etc.
teichoic acid interact with cell wall. attach to peptidoglycan, stick out with a degree of variability, causing different immune response, etc.
LPS components
1. Lipid A: embedded in membrane of outer leaflet (2nd membrane)
-highly conserved, toxic
2. Core Structure: 8-10 sugars. usually unique (such as KPO)
-link to outer world
3. O side chain: Repeating tetra or penta sugars
-very hydrophillic, repeat between 3-40 times.
-highly conserved, toxic
2. Core Structure: 8-10 sugars. usually unique (such as KPO)
-link to outer world
3. O side chain: Repeating tetra or penta sugars
-very hydrophillic, repeat between 3-40 times.
LPS toxicity
Low quantities: Local inflammation
Moderate quantities: systemic response such as fever
High quantities (such as in case of bacteremia): Septic shock [can lead to DIC]
Moderate quantities: systemic response such as fever
High quantities (such as in case of bacteremia): Septic shock [can lead to DIC]
DIC- disseminated intravascular coagulation
can be caused by high conc. of LPS, many little clots occur in the whole body, can cause multiple organ failure.
About this deck
By: Andrew McCanna
Created: 2012-01-18
Size: 17 flashcards
Views: 5
Created: 2012-01-18
Size: 17 flashcards
Views: 5
About StudyBlue
STUDYBLUE makes things that make you better at school.
Things like online flashcards with photos and audio.
Things like personalized quizzes and friendly reminders about when (and what) to study next.
Think of it as a digital backpack™: access to all of your study materials online and on your phone.
STUDYBLUE exists to make studying efficient and effective for every student, for free. Join us.
“I have used this website for three exams, and I see a huge difference in my test results.”
Naj
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