Renal - Pathology
Medical Anatomy And Physiology 1 with Me at University of Louisville
About this deck
By: Melissa Huscusson
Created: 2011-04-28
Size: 56 flashcards
Views: 21
Created: 2011-04-28
Size: 56 flashcards
Views: 21
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What does the presence of casts indicate?
Hematuria/pyuria is of renal origin
What are granular casts indicative of?
Acute tubular necrosis
EM: subepithelial immune complex humps?
Poststreptococcal glomerulonephritis
What kidney disease may present with peripheral and periorbital edema?
Poststreptococcal glomerulonephritis
What diseases may result in rapidly progressive glomerulonephritis?
Goodpasture sndrome
Wegener's granulomatosis
Microscopic polyarteritis
Wegener's granulomatosis
Microscopic polyarteritis
What is contained in the crescent of RPGN?
Fibrin
Plasma proteins
Glomerular parietal cells
Monocytes
Macrophages
Plasma proteins
Glomerular parietal cells
Monocytes
Macrophages
What are two causes of diffuse proliferative glomerulonephritis?
SLE
MPGN
MPGN
Subendothelial DNA-anti-DNA ICs?
Diffuse proliferative glomerulonephritis
What is the most common cause of death in SLE?
Diffuse proliferative glomerulonephritis
ICs in mesangium?
Berger's disease
What disease presents with a URI?
Berger's disease
What disease presents with acute gastroenteritis?
Berger's disease
What is the pathophysiology of Alport's syndrome?
Autoantibodies to type IV collagen --> split basement membrane
What are three extrarenal manifestations of Alport's syndrome?
Nerve disorders
Ocular disorders
Deafness
Ocular disorders
Deafness
What is SLE's nephrotic presentation?
Membranous glomerulonephritis
LM: diffuse capillary and GBM thickening?
Membranous glomerulonephritis
EM: spike and dome appearance with subepithelial deposits?
Membranous glomerulonephritis
What disease involves selective loss of albumin?
Minimal change disease
EM: foot process effacement?
Minimal change disease
What disease is often triggered by a recent infection?
Minimal change disease
What is the pathophysiology of diabetic glomerulonephropathy?
Nonzenzymatic glycoslation of GBM --> increased permeability, thickening
NEG of efferent arterioles --> increased GFR --> mesangial expansion
NEG of efferent arterioles --> increased GFR --> mesangial expansion
LM: nodular glomerlosclerosis?
Diabetic glomerulonephropathy
What is the most common glomerular disease in HIV patients?
Focal segmental glomerulosclerosis
LM: segmental sclerosis and hyalinosis?
Focal segmental glomerulosclerosis
What syndrome is associated with HBV?
MPGN Type I
What syndrome is associated with C3 nephritic factor?
MPGN Type II
EM: GBM splitting?
MPGN Type I
EM: dense deposits?
MPGN Type II
Which type of kidney stones are the most radiopaque?
Calcium
Which type of kidney stones are always radiolucent?
Uric acid
Which type of kidney stones are worsened by alkaluria?
Ammonium magnesium phosphate (struvite)
What is the cause of struvite stones?
Infection with urease-positive bugs (Proteus, Staph, Klebsiella)
How do you treat cystine stones?
Alkalinzation of urine
What is a genetic association of renal cell carcinoma?
von Hippel-Lindau: gene deletion on chromosome 3
Where does renal cell carcinoma metastasize?
Lung/bone
What is the WAGR complex?
Wilms' tumor
Aniridia
Genitourinary malformation
Retardation
Aniridia
Genitourinary malformation
Retardation
What does painless hematuria suggest?
Bladder cancer
Which drugs can cause drug-induced interstital nephritis?
Diuretics
NSAIDs
Penicillin derivatives
Sulfonamides
Rifampin
NSAIDs
Penicillin derivatives
Sulfonamides
Rifampin
What are two associations with diffuse cortical necrosis?
Abruptio placentae
Septic shock
Septic shock
What is the pathophysiology of diffuse cortical necrosis?
Vasospasm + DIC --> acute generalized infarction of cortices of both kidneys
What is a common electrolyte imbalance noted in acute tubular necrosis?
Hyperkalemia due to decreased secretion
What are four associations with renal papillary necrosis?
Diabetes mellitus
Acute pyelonephritis
Chronic phenacetin use (acetaminophen)
Sickle cell anemia
Acute pyelonephritis
Chronic phenacetin use (acetaminophen)
Sickle cell anemia
What is the BUN/Cr in prerenal azotemia?
>20
What is the BUN/Cr in intrinsic renal failure?
BUN/CR < 15
What is the BUN/Cr in postrenal obstruction?
> 15
What are the two main causes of chronic renal failure?
Hypertension
Diabetes
Diabetes
What is the most common cause of acute renal failure?
Acute tubular necrosis
What is Fanconi's syndrome?
Decreased proximal tubule transport of amino acids, glucose, phosphate, uric acid, protein, and electrolytes
What are three causes of Fanconi's syndrome?
Wilson's disease
Glycogen storage diseases
Drugs (cisplatin, tetracycline)
Glycogen storage diseases
Drugs (cisplatin, tetracycline)
What heart condition is associated with ADPKD?
Mitral valve prolapse
What is indicated by U waves on EKG?
Hypokalemia
What is the best method of diagnosing diabetic nephropathy?
Microalbuminuria detection
What do the granular deposits consist of in poststreptococcal glomerulonephritis?
IgM, IgG, C3
What is a common complication of medullary sponge kidney?
Kidney stones
Adult polycystic kidney disease inheritance and gene mutation
AD mutation in APKD1 or APKD2
Infantile polycystic kidney disease inheritance
AR
About this deck
By: Melissa Huscusson
Created: 2011-04-28
Size: 56 flashcards
Views: 21
Created: 2011-04-28
Size: 56 flashcards
Views: 21
About StudyBlue
STUDYBLUE makes things that make you better at school.
Things like online flashcards with photos and audio.
Things like personalized quizzes and friendly reminders about when (and what) to study next.
Think of it as a digital backpack™: access to all of your study materials online and on your phone.
STUDYBLUE exists to make studying efficient and effective for every student, for free. Join us.
“I have used this website for three exams, and I see a huge difference in my test results.”
Naj
Naj