Spirochetes
Microbiology 1 with Swierkosz at Saint Louis University
About this deck
By: Brian Nguyen
Created: 2011-02-11
Size: 27 flashcards
Views: 2
Created: 2011-02-11
Size: 27 flashcards
Views: 2
About StudyBlue
STUDYBLUE makes things that make you better at school.
Things like online flashcards with photos and audio.
Things like personalized quizzes and friendly reminders about when (and what) to study next.
Think of it as a digital backpack™: access to all of your study materials online and on your phone.
STUDYBLUE exists to make studying efficient and effective for every student, for free. Join us.
“Simply amazing. The flash cards are smooth, there are many different types of studying tools, and there is a great search engine. I praise you on the awesomeness.”
Dennis
Dennis
Sign up (free) to study this.
Trepanoma pallidum
Spirochete
Causes syphilis
Can't be cultured, sensitive to heat/light, need special dark field microscope to image
T. pallidum pathogenesis
No exo/endotoxin produced
Excretes hyaluronidase to disrupt ground substance
Transmitted through sexual contact or transplacentally
Breaks in skin, invades mucous
Syphilis stages of disease
Primary - chancre at site of innoculation, spreads to
Secondary - organisms disseminate through blood and lymph to create foot/hand rashes. also hepatitis, meningitis, glomerulonephrotitis
Latent - goes away, may last 3-30 years
Tertiary - gummas of skin, also CNS degeneration
Syphilis - congenital symptoms
Can cause fetal death, spontaneous abortion, still birth
Surviving infants have CNS damage, congenital anomalies, rash, snuffles
Treat with maternal testing and antibiotics
T. pallidum diagnosis
Dark field microscope of lesion
Otherwise serological test
Borrelia burgdorfei
Large spirochete, causes Lyme disease
No endo/exotoxin
Lyme disease - disease progression
Bite, first stage (erythema migrans w flu-like symptoms)
2nd stage - organisms spread to musculoskeletal sites, CNS - arthritis, arthralgia
3rd stage - chronic arthritis/CNS disease by auto-immune
Lyme disease - diagnosis
Can be cultured, but difficult to grow
Serological tests have cross-reactivity with other spirochetes
PCR
Borrelia recurrentis (vector, disease, dx)
Causes relapsing fever, flu-like symptoms
Endemic - tick, epidemic - louse
Fatal - invasion of heart, kidney, liver, spleen
Dx - spirochetes in blood smear
Leptospira interrogans (pathogenesis, epidemiology, disease, dx)
Causes leptospirosis
Hooked ends adhesins, then burrow
Biphasic infection - flu like, then systematic (fatal?!)
Serological dx
Mycoplasma pneumoniae (epidemiology, disease, pathogenesis)
Transmitted through inhaled aerosolized respiratory secretions (P2P)
Walking pneumonia
Organisms travel to lower RT, adhere with P1 adhesins, impede ciliary movement, damage caused by immune reaction
Produces H2O2 - cytotoxicity, hemolytic anemia
M. pneumoniae (diagnosis)
Antibodies produced cause cold agglutinination
Chlamydiae properties
Obligate intracellular
Grow inside inclusion bodies (elementary body, reticular body)
C. trachoma (serotypes, disease)
A,B,C - trachoma eye disease
D- K - genitourinary STDs (nongonococcal urethritis)
L1-L3 - Lymphogranulomavenerum
Trachoma
Chronic keratoconjunctivitis
P2P contact, flies
Repeated infections lead to scarring and blindness
Lymphogranuloma venerum
Invasive STD, uncommon in US
Transient papule on external genital, leads to painful swelling of local lymph nodes
Chlamydiae diagnosis
Scrape lesions for organisms
Hard to culture, need cells for it to colonize
Serotyping, direct immunofluoresence
Chlamydia/Chlamydophila pneumoniae
Atypical pneumonia
Only humans
Chlamydia psittica
Parrot based
Affects lower resp. tract
Causes flu-like symptoms, fever, dry cough
Possible hepatitis, splenomegaly
Rickettsiae
Obligate intracellular parasites
Vector borne
Small gram neg, doesn't stain well
Causes generalized infections - rash, vasculitis, fever, headache
Dx by clinical signs, history, maybe serology
Rickettsiae (pathogenesis)
Infects vascular endothelial cells, binds w adhesins, uptake
PLA used to break out of phagolysosomes and to break out of cell
Mobilizes actin to enter adjacent cells
Spreads in blood, causes thrombi in skin
Leads to high fever, malaise, HA, vasculitis
R. rickettsii
Rocky mountain spotted fever
South central, mid-atlantic coast
Acute onset, high fever, HA, malaise, rash (petechial, hemorrhagic)
Disseminates to DIC, circulatory collapse
Rocky mountain spotted fever rash
Rash starts peripherally, palms and soles
Moves centripetally and becomes hemorrhagic
R. akari
Rickettsialpox
In Japan/US
Mite vector, causes eschars at bite
R. prowazekii
Epidemic typhus
Only in humans
Louse vector
Rash starts on the trunk, moves outward sparing palms and soles
Ehrlichia (Anaplasma)
Obligate intracellular parasite of leukocytes (Monocytes, granulocytes)
Replicates in cytoplasmia vacuoles
Not often a rash
S. central US
ID through morulae, PCR, serology
Coxiella burnetti
Q fever
No arthropod vector
Spore-like structure
Transmitted through inhalation, abrasion, or ingestion
From dried animal products
Reproduces in RT, causes atypical interstitial pneumonia
About this deck
By: Brian Nguyen
Created: 2011-02-11
Size: 27 flashcards
Views: 2
Created: 2011-02-11
Size: 27 flashcards
Views: 2
About StudyBlue
STUDYBLUE makes things that make you better at school.
Things like online flashcards with photos and audio.
Things like personalized quizzes and friendly reminders about when (and what) to study next.
Think of it as a digital backpack™: access to all of your study materials online and on your phone.
STUDYBLUE exists to make studying efficient and effective for every student, for free. Join us.
“Simply amazing. The flash cards are smooth, there are many different types of studying tools, and there is a great search engine. I praise you on the awesomeness.”
Dennis
Dennis