teratogens & causes of congenital defects

United States Medical Licensing Examination Step 1 No with Dr.goopstar at University of Virginia

About this deck

By: Ankur Gupta
Created: 2011-12-11
Size: 30 flashcards
Views: 6

About StudyBlue

STUDYBLUE makes things that make you better at school. Things like online flashcards with photos and audio. Things like personalized quizzes and friendly reminders about when (and what) to study next. Think of it as a digital backpack™: access to all of your study materials online and on your phone. STUDYBLUE exists to make studying efficient and effective for every student, for free. Join us.

“I have used this website for three exams, and I see a huge difference in my test results.”
Naj

Sign up (free) to study this.

ACE inhibitor

renal damage

alcohol

FAS, mental retardation, microcephaly, VSD, ASD, ADD

alkylating agents

(cyclophosphamide, busulfan, cisplatin)

absence of digits, multiple anomalies

aminoglycosides

ototoxic

cocaine

IUGR, placental abruption, microcephaly, low birth weight, renal agenesis, congenital heart defect

diethylstilbestrol

DES - vaginal adenosis / clear cell adenocarcinoma, mullerian defects

folate antag

Neural tube defects

iodide

lack OR excess

cretinism

lithium

ebsteins anomaly - atrialized right ventricle

meternal diabetes

caudal regression syndrome (agenesis of lumbar spine / sacrum - flaccid paralysis of legs, urinary incontinence, extreme = anal atresia / sirenomelia)

smoking

IUGR, preterm labor, placental abnormalities, ADHD

tetracyclines

discolored teeth

thalidomide

limb defects (amelia, phocomelia), deafness

valproate

folate antagonist, autism

vit A excess

spontaneous abortion, cleft palate, cardiac defects

warfarin

bone deformities, fetal hemorrhage, abortion

nasal hypoplasia, agenesis corpus callosum

phenytoin

nail and distal phalynx hypoplasia, cleft lip / palate, neuroblastoma, bleeding (Vit K deficiency)

isotretinoin

hearing defects, missing ear lobes, visual impairment, facial dysmorphism, mental retardation, CNS defects, CV defects

Toxoplasmosis

maternal - aysmptomatic, some lymphadenopathy

fetal - triad = chorioretinitis, hydrocephalus, intracranial calcifications

also IUGR, hepatosplenomagaly, deafness

rubella

maternal - rash, lymphadenpathy, arthritis

fetal - triad = PDA, cataracts, deafness. sometimes blueberry muffin rash

also hepatsplenomeg, thrombocytopenia

CMV

maternal - asymptmatc, mono like symptoms

fetal - hearing loss, seizures, petechial rash

IUGR, CNS calcification (periventricular), intranuclear inclusions in URINE

HIV

maternal - usual

fetal - recurrent infections, chronic diarrhea, oral thrush, intracranial calcifications, failure to thrive

Herpes simplex

maternal - asymptomatic, vesicular lesions

fetal - temrporal encephalitis, herpetic (vesicular lesions)

IUGR, keratoconjunctivitis, microcephaly

syphilis

maternal - depends on primary secondar tertiary

fetal - stillbirth, hydrops fetalis, facial abnormalities (botched teeth, saddle nose, short maxilla), saber shins

22q11 syndromes (e.g. DiGeorge)

Persisten truncus arteriosus

Tetralogy of Fallot (pulm stenosis, RVH, overiding aorta, VSD)

Down syndrome

AV septal defect (endocardial cushion defect) !!!

ASD, VSD,

Congenital rubella- what are the heart effects?

PDA !!!

Septal defects

Pulmonary artery stenosis

Turner syndrome

Coarctation of aorta (preductal)

Marfan's syndrome

aortic insufficiency (as a late complication, not congenital)

Cardiac abnormality in infant of diabetic mother

transposition of great vessels

About this deck

By: Ankur Gupta
Created: 2011-12-11
Size: 30 flashcards
Views: 6

About StudyBlue

“I have used this website for three exams, and I see a huge difference in my test results.”
Naj