- University of California - Los Angeles
- Life Sciences
- Life Sciences 3
- 10/15/10 LECTURE
- The sigma factor tells the polymerase where to bind in order to start transcription
- recognizes specific DNA sequences and there are multiple sigma factors in cells that recognize different sequences (in prokaryotes)
- RNA polymerase is recognizing specific region in DNA promoter whcih promotes transcription
- Coding region is always in positive territory
Divergent promoters have the polymerase moving away from each other
- For -35: TTGACa (where a is conserved and has more variation)
- For -10: TAtAaT it has two positions that are less conserved
- This increases the frequency of transcription and the closer you are to the match is less conserved
- Sigma4 binds/recognizes the sequence at -35 and sigma2 binds/recognizes the sequence at -10.
- The bottom strand is used as the template
- sigma32-It has heat shock genes
- heat up bacteria to high denaturation.
- sigmaE- Genes for envelope integrity
- gigma28- Flagellum assembly and chemotaxis
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