(T/F) Arabian PSCID foals have high mortality when infected with Equine adenovirus
What occurs in the lung of of PSCID foal infected with Ad?
There is very extensive bronchopneumonia. The lungs have failed to collapse. On the cut surface of the lung, essentially all bronchi are plugged with thick, cream coloured exudate.
(T/F) In equine AdV infection, the villi of the duodenum are unaffected.
F. Duodenal villous atropy 6 days after experimental infection: absence of tall villi
(T/F) AdV are the ONLY viruses with a fiber (the fiber Ag) protruding from each of the 12 pentons.
T. The fiber is the structure of attachment to host cells and is also a type specific hemagglutinin. The fiber Ag attaches to a specific host cell receptor and initiates replication!
(T/F) AdV are sensitive to trypsin and lipid solvents.
F. AdV are RESISTANT to trypsin and lipid solvents, and moderately resistant on premises.
Which AdV structure contains a cross-reacting group antigen?
Where does replication and subsequent processes occur following AdV infection?
Viral DNA replication, mRNA transcription and virion assembly occur int he nucleus, utilizing both host and virus-encoded factors. This results in the formation of basophilic and/or acidophilic intranuclear inclusions.
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