Last Modified: 2016-03-08
become proto-oncogenic through mutation
activated by FAS and TNFR1
final molecule involved in both 'Death Receptor' and 'Stress-induced' apoptosis pathway
pro and anti apoptotic
Cyclin E/Cdk2 mediates cell entry into S-phase
Cyclin A/Cdk2 mediates entry into G2-phase
Cyclin B/Cdk2 regulates entry into Mitotic cycle
heterodimeric serine/threonine kinases help regulate cell-cycle progression, transciption and neuronal f(x)
cell cycle progression is not dependent on
endocrine and hematopoietic development depend on proper f(x)
ct antagonistically to inactivate GTPases by increasing their intrinsic rate of GTP hydrolysis. GDP remains bound to the inactive GTPase until a GEF binds and stimulates its release.
inactive form is bound to GDP
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