WEEK OF MARCH 23 STUDY QUESTION: Name some common drugs of abuse that can produce psychotic reactions similar to schizophrenia. EARLY ANTIPSYCHOTIC DRUGS1950s:reserpinechlorpromazine (Thorazine)double-blind, placebo controlled studies;not just acting like sedatives; about 70-75 % of patients show therapeutic effectsMechanism of action unknown at that time, but researchers did notice that Parkinsonian symptoms generally were induced at doses that successfully treated disorder.Drugs also known as ?neuroleptics? and ?major tranquilizers?BASIC RESEARCH AND DEVELOPMENT OF ANTIPSYCHOTIC DRUGSJanssen et al. 1965Is it possible to predict the clinical effects of neuroleptic drugs (major tranquilizers) from animal data?What do antipsychotic drugs do in behavioral tests?Suppress locomotion, rearing, block amphetamine locomotion, apomorphine stereotypy, block avoidance responding, induce ?cataleptic immobility?; these drugs general suppress a wide variety of activities
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