Both norepinephrine and serotonin presynaptic reuptake inhibition, at high doses dopamine as well
Side effects similar to SSRIs
Dose related increase in blood pressure
Very few drug interactions, very useful in patients on numerous medications Also approved for treatment of Generalized Anxiety Disorder
Serotonin and norepinephrine reuptake inhibition Far less like than Effexor to cause dose related hypertension Also indicated for depression and diabetic neuropathic pain but also used for other pain symptoms
Complex and unique action of all antidepressants Antagonist at central PRESYNAPTIC a 2 adrenergic autoreceptors
Antihistaminic properties dramatically increase appetite and weight gain is a serious concern.Rare cases of agranulocytosis but routine monitoring of CBC has not been recommended.
Rarely used for the treatment of depression at this time.Most common use is for insomnia in low doses. Risk of priapism