What is the overall incidence of hereditary breast cancer?
What is BRCA1?
A human care taker gene produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. BRCA1 is expressed in the cells of breast and other tissue, where it helps repair damaged DNA, or destroy cells if DNA cannot be repaired. If BRCA1 itself is damaged, damaged DNA is not repaired properly and this increases risks for cancers (see BRCA mutation).Tumor suppressor gene
What is BRCA2?
BRCA 2- carries out instructions to make a protein. BRCA2 belongs to the tumor suppressor gene family, and orthologs have been identified in most mammals for which complete genome data are available.The protein encoded by this gene is involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double strand breaks.
A tumor suppressing TF that induces expression of cell death genes and genes like p21 (cyclin-CDK inhibitor), which gives cells time to fix DNA damage during cell cycle.
what is p53?
TP53 is a tumor suppressor gene that has a major role in determining the fate of cells that contain damaged DNA. The gene product, tumor protein p53, can delay cell cycle progression, permitting an opportunity for DNA repair or initiation of programmed cell death (apoptosis). In the absence of the normal activated p53 protein, cells containing damaged DNA can survive and proliferate, which contributes to malignant transformation.