-developed by Walter Sutton
-proposed that genes are present on chromosomes
-based on observations that homologous chromosomes pair with each other during meiosis.
-supportin evidence was provided by work with fruit flies
-controlled by genes present on the x chromosome.
-shows inheritance patterns different than those of genes on autosomes
-uniparental (one parent) inheritance from the mother.
-humans who have gained an extra autosome and they do not survive.
-down syndrome is trisomy of chromosome 21
-humans who have lost even one copy of an autosome
-they generally do not survive embryonic development
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