Synthase binds ATP and the appropriate aa to form aminoacyl-adenylate (release pyrophosphate Ppi)
The newly formed complex binds to the corresponding tRNA molecule, and the aa is transferred from the aa-AMP to 3’ OH of tRNA
-some mediate a proofreading reaction also… if the tRNA is found to be improperly charged, the aminoacyl-tRNA bond is hydrolyzed
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