Any foreign molecule that can trigger specific immune response (production of antibodies)
Definition of an antibody?
Defense protein secreted by specific B lymphocytes "Y" shape variable regions bind antigen constant region involved in effector mechanism
What is the roles of MHC proteins?
to identify "self" from "non-self"
MHC class 1
on all nucleated cells recognized by cytotoxic t cells
MHC class 2
on macrophages, B cells, and dendritic cells, recognized by helper T cells
Plasma cells are derived from ? What do they produce?
Derived from activated B cells antibody factories
Where do macrophages come from? What do they do?
They are derived from monocyte lineage they phagocytize the antigen
Where are mast cells from? What do they do?
Derived from bone marrow release histamine, important for vasodilation/ inflammation
What is the antigen for blood types A, B, AB, and O? The antibodies?
A = antigen A, anti-B B = antigen B, anti-A AB = antigen AB, none O = no antigen, anti-A and anti-B
Blood types Rh+ and Rh- have what antigen/antibody?
Rh + = antigen Rh, none Rh - = none, anti-Rh
What is RHOGAM?
it is a drug given to a pregnant woman just before going into labor. If a mother is Rh - and the baby is Rh + then the mother would produce antibodies if exposed to the fetal blood. This drug prevents the mother from creating antibodies.
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