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components contained in a bag of whole blood
platelets and white cells
starting point dosage for whole blood
specific use for packed red cells?
used specifically for anemia (no clotting factors or platelets)
initial dose is 6-10ml/kg
uses for fresh frozen plasma
used to treat congenital deficiency of clotting factors: von Willebrand disease,
Hemophilia A and B
acquired coagulopathies, rodenticide, coagulopathy, DIC.
conditions in which you would NOT want to use fresh frozen plasma
don't use a source of albumin, do not use for volume expansion, not a source for nutritional support.
multiple doses may be required due to short half life of clotting factors.
what condition is cryoprecipitate given?
treatment of choice for vWd.
3 common sources of blood components
commercial blood bank
in-house blood donors
canine blood groups are classified by the
DEA (dog erythrocyte antigen)
two most clinically significant canine blood groups are
do dogs have any clinically important alloantibodies present prior to sensitization with blood transufion?
antibody against different blood group occurs when?
5-10 days after first transfusion.
second transfusion would cause hemolytic crisis.
all canine donors, at minimum, should be DEA __
what are the three feline blood types?
what type of breed is common type B cat?
what will happen if a type B cat receives type A blood?
results in hemolysis within 2-3 days.
reaction can occur on first transfusion because cats have naturally occuring antibodies.
do cats with AB have alloantibodies?
what type of blood should a type B cat get?
type-specific blood if available but type A if not available.
they should not get type B!
mixing recipient plasma and donor cells
mixing donor plasma and recipient cells.
what is the ultimate goal with blood transfusion?
correct clinical signs
___ml/kg of pRBCs raises PCV 1%
three classes of transfusion reactions
common example of acute immunologic hemolytic transfusion reactions
immune mediated hemolysis. antibodies that elicit immune responses are present in the plasma of the donor or recipient.
rapid, irreversible, fatal.
febrile non-hemolytic reactions
temp increases more than 1 degree during transfusion.
likely due to leukocyte derived cytokines.
administer NSAIDS and stop transfusion.
acute allergic reactions
mild to severe
may be IgE mediated to soluble substances in donor plasma
if mild-temporarily discontinue transfusion and give diphenhydramine.
3 examples of acute reactions that are not immune mediated
non immune-mediated hemolysis
transfusion associated sepsis.
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