refer to as GROWTH rather than reproduction -this is how bacterial cells grow/divide -chromosomes duplicate, go to diff sides of cell -elongate -divide
-site of Fts and min proteins
FtsZ / FtsZ ring
-key Fts protein in cell division -forms a contractile ring that pinches off -related to tubulin
-help identify location of midpoint in cell where the cell will divide (minCD)
Mutant cells lacking minCD gene
divide unevenly to generate one large cell and one mini-cell
-necessary for rod shape -forms polymers -similar to actin
-lipid carrier molecule -acts as the peptidoglycan precursor CONVEYOR -transport the NAM/NAG/pentapeptide peptidoglycan precursor across the cytoplasmic membrane to the site of cell wall synthesis
-FINAL step of peptidoglycan cell wall synthesis -cross-links layers of peptidoglycan to each other
Peptidoglycan Cell Wall Synthesis OVERVIEW
1. Bactoprenol activity (starts at FtsZ ring) 2. Transpeptidation reaction
1. Bactoprenol activity
- Bactoprenol transports NAM/NAG/pentapeptide peptidoglycan precursors to the site of cell wall synthesis. - AUTOLYSINS create small openings in the PRE-EXISTING cell wall. - NEW cell wall material is then ADDED across these openings.
2. Transpeptidation reaction
-cross-links the layers of peptidoglycan to each other.
Why must the introduction of NEW cell wall precursors into the EXISTING wall be TIGHTLY coordinated?
if not coordinated tightly and properly, AUTOLYSIS (spontaneous cell lysis) can occur!!
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