have not encountered antigen - circulate in the blood and lymph and are carried to the secondary lymphoid organs, most notably the spleen and lymph nodes
consequence of activation - progressive increase in the average affinity of the antibodies produced sa the response to activation proceeds.
progenitor B cell (pro-B cell)
earliest distinctive B-lineage cell
will not develop further without stromal cell environment
precursor B cells (pre-B cells)
with the help of microenvironment provided by the bone marrow stromal cells directly interacting with pro-B cells as well as secreting various cytokines (most notably IL-7) proliferate and differentiate into...
on completion of heavy-chain rearrangement --> cell is classified as a
immature B cell
completion of light-chain rearrangement --> cell is classified as an