uncontrolled proliferation of cells **normal controls on cell division break down
four stages to a typical mammalian cell cycle
G1, S, G2, and M
**adding up to 24 hours per cell cycle
cells that are not dividing such as adult somatic cells are said to be in stage G0
when does centrosome duplication occur?
**begins in G1 and is completed in S-phase
when does DNA duplication in the nucleus occur?
**takes place in the S phase and must be completed before G2 can begin
**cell division cycle **Hartwell isolated a large # of conditional lethal (Temp-sensitive) mutants aka cdc that were blocked at a particular step of the yeast cell cycle when grown at a high Temp but could grow normally at a lower Temp..they grow till the missing protein is needed