Last Modified: 2011-07-04
Related Textbooks:Pharmacology (Lippincott's Illustrated Reviews Series)
concentration of the drug-receptor complex, the more stable is that complex, and the greater is the affinity of the drug for the receptor
– It also causes the loss of three rotational and three translational degrees of
– The more drugs bound to the receptor the greater the response (receptors can The more drugs bound to the receptor, the greater the response (receptors can
– Drugs that associate with then rapidly dissociate from the receptor, allow
hd l l b li ihh hihi another drug molecule to subsequently interact with the receptor, which is expected to produce a greater response.
occurs in the receptor to allow for effective binding.
–This theory suggests that the receptor does not normally exist in the proper
conformation for drug binding, and dissociation of the drug from the receptor
allows the receptor to revert to its original form.
rate of their existence determines the observed biological response.
– Agonists produce the specific perturbation required for a biological
response, while antagonists produce a non-specific perturbation which fails to produce a biological response.
active and inactive states. Agonists function by shifting the equilibriu
toward the active state, while antagonists prevent the active state.
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