Large complex enveloped viruses with dsDNA genome (encodes 50-80 proteins)
Replication and assembly occurs in cell nucleus, budding thru nuclear and Golgi membranes produces envelope; then “exocytosed”
prot made in cyto. with ribosomes
Electron microscopy (EM), similar structure; there are differences in Ag and DNA composition; herpes simplex (HSV) types 1 and 2 share some protein Ag and DNA homology, but people can have infections with both viruses
Encounter and Entry of Herpes -% w/ Ab?
66-75% of adults have Ab against HSV 1; 18-50% of adults have Ab to HSV 2 depends on population bc ppl that are sexually active/multiple partners have a higher risk
10 fold (order of magnitude) increase in HSV 2 infections from 1965- 1995
-in the environment?
Many HSV infections are asymptomatic
Virus is susceptible to drying, heat, detergents, and solvents (because of envelope) - hand sanitizer works well
Don't survive well on environmental surfaces- need direct inoculation of virus from person to person