Fatty Acid Synthesis
Last Modified: 2016-03-08
- production of cytosolic acetyl CoA
- Carboxylation of Acetyl CoA to form Malonyl CoA
- Fatty Acid Synthase, a multienzyme complex
citrate is transported into the cytosol.
citrate lyase is induced by insulin.
acetyl CoA carboxylase
biotin is the coenzyme
negative - long chain fatty acyl CoA
positive - citrate
9 acetyl CoA + 14 NADPH + 14H+ + 7ATP
Palmitic acid + 8 CoA + 14NADP+ +7ADP + 7Pi + 7H20
NAP+ dependent malate dehydrogenase
malate is the precursor
they are located in the mitochondria
they are reversal of fatty acid beta-oxidation enzymes
they are located in sER.
resemble the mini-ETC system with Cytochrome B
- delta-4 desaturase
- delta-5 desaturase
- delta-6 desaturase
- delta-9-fatty acyl-CoA desaturase
-> [enzyme A] - acyltransferase
-> [enzyme B] - acyltransferase
phosphatidic acid (DAG phosphate)
-> [enzyme C] - phosphatase
-> [enzyme D] - acyltransferase
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