*Med or substance that is metabolized by the isoenzyme, utilizing the enzyme in order to be modified so it can reach drug site of action and/or be eliminated *CYP450 3A4 substrates: about 50% of all Rx meds *ex) sildenafil (Viagra), atorvastatin, simvastatin, venlafaxine (Effexor), alprazolam (xanax), many more!
*An inhibitor blocks the activity of the isoenzyme, limiting substrate excretion, allowing increase in substrate levels and possible risk of substrate-induced toxicity *Many! *Some strong inhibitors: Erythromycin, clarithromycin, HIV retrovirals, SSRIs, gemfibrozil, antifungals, Grapefruit juice, saboxone
*Med or substance that accelerates the activity of the isoenzyme so that substrate is pushed out the exit pathway, leading to reduction in levels *St. John's Wort, antiretrovirals, combined oral contraceptives, cyclosporine (immunosuppressant)
Corticosteroid side effects
long term corticosteroid therapy side effects
osteoporosis, dvlp moon-shaped face, increased risk of infection, muscle wasting of `extremities
What are the common side effects of long-term corticosteroid therapy?
Decrease growth in children, Glaucoma, Centripetal distribution of body fat, Increased risk of infection, Hirstuism, Increased appetite, Emotional Disturbance, Hypertension, Peripheral Edema, Peptic Ulcer, Hypokalemia, (Hyperglycemia for DM patients)