Growth Factors, Proto-oncogens, and Tumor suppressor genes
- University of Louisville
- Nursing 338
- Growth Factors, Proto-oncogens, and Tumor suppressor genes
Last Modified: 2011-07-14
Related Textbooks:Essentials of Pathophysiology: Concepts of Altered Health States
Epidermal Growth Factor.
Source: activated macrophages, Keratinocytes, and other cells.
Function: mitogenic for keratinocytes and fibroblasts; simulates keratinocyte migration and granulatin tissue formation
Vascular Endothelial cell Growth Factor
Source: Mesenchymal cells
Function: increases vascular permeability; mitogenic for endothelial cells of blood vessels.
Fibroblast Growth Factor
Source; macrophages, mast cells, T lymphocytes, endothelial cells, fibroblasts, and many other tissues.
Function: chemotactic for fibroblasts, mitogenic for fibroblasts and keratinocytes; stimulates angiogenesis, would contraction, and matrix deposition.
- a normal gene that codes for many parts of the cellular communication pathway.
- Ras, ERBB, MYC
- this communication effects cell proliferation and cell shape.
- responds only when needed, a control mechanism.
- "the watchmen of the cell"
- p53, RB1, BRCA1, BRCA2.
- located at stop checkpoints at various locations in the cell cycle
- activated if there is an error during growth or replication
- if there is a problem these proteins can hold the cell cycle
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