blood, bone marrow, lymph nodes, payer's patches, and spleen
where do memory b cells reside?
generally in lymphoid tissues, spleen, and many in the blood
where do t cells reside?
blood, lymph nodes, Payer's patches, and spleen
where are naive t cells found?
where can memory t cells be found?
lymphoid and nonlymphoid tissues (lung, liver, intestine)
what are the characteristics of bone marrow?
primary lymphoid organ
main site of production of cells in the innate immunity
main site of production of b cells
produces precursors of t cells
what are the characteristics of the thymus?
main site of production of naive antigen unexperienced T cells
formed early in life and reaches max size in puberty
production of naive t cells is proportional to the size of the thymic tissue
describe t cell maturation:
immature t cells interact with DCs, thymic epithelial cells during the process of maturation and only cells with Tcell receptors of intermediate affinity to self-antigens survive because dcs and mTECs express many self peptides and ensure removal of a large number of self-specific t cells NEGATIVE SELECTION
What are the summary points of the lecture?
-B cells are produced in the bone marrow; self reactive b cells are deleted during the maturation process -T cells mature in the thymus; T cells with too strong or too weak reactivity to self-antigens are deleted
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