Autoimmune review. Immunological Tolerance Centeral Tolerance: After medullarly development, the T-Cells develop in the Thymus. Autoimmune T-cells destroyed in the Thalamus Peripheral Tolerance: Cells prevent some cells that prevent the expansion of T-cells attempting to develop an attack against self. Acquired Tolerance: In pregnancy, the body gets a tolerance for the fetus. Congenital Adrenal Hyperplasia: Blocked production of Aldosterone and Cortisol Prognosis of adrenocortical insufficiency: Fatal before glucocorticoid and mineralocorticoid therapy. Survival is normal. Cushing's syndrome: Untreated 50% died in 5 years. Adrenal adenomas removed by unilateral adrenalectomy with ~100% cure. GI Tract 4 established GI hormones Sugar does not activate the GI tract very much. Good for athletes who do not want to loose blood supply to the GI tract. Somatostatin: Regulation of cell types: Endocrine, Paracrine, Neurocrine, Autocrine
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