Md Immunology Topic 7 - T Cell Development, Activation And The Tcr
What progenitor cells does T cell derives from?
2 steps of T cells development
1. Positive selection: selection for self-MHC 2. Negative selection: selection against those having receptors recognizing self-antigens
What is immature T cell called?
MHC restriction is:
AKA self-MHC restriction, the ability of T cells to recognize only our own MHC molecules
2 types of TCRs
1. αβ TCR - consists of 1 α chain and 1 β chain . More numerous and diverse 2. γδ TCR - consists of 1 γ chain and 1 δ chain . Interact with non-classical MHC molecules . Found in specific tissues (peripheral lymphoid, epithelial cells, intestines, etc.)