Membrane associated glycoprotein molecules whose function is to bind peptide antigens and present them to T-cells.
What does MHC stand for?
Major Histocompatibility Complex
How was MHC discovered?
Many genes influence tissue transplantation success, but one genetic locus was shown to have a greater effect than others.
What is Human Leukocytic Antigen?
MHC in humans, specifically. MHC was discovered in mice. HLA is only in humans.
What is the function of MHC I?
Binding and transport of peptide antigens generated in the cytosol to the cell surface for recognition by CD8 / Cytotoxic T-cells. Also involved in IgG uptake in the gut, iron metabolism, and NK cell function regulation.
What is the function of MHC II?
Binds and transports antigens generated in endocytic vesicles to the cell surface for recognition by CD4 / Helper T-cells.