What is the term for the administration of all or part of a microbe or a modified product of that microbe to evoke a immune response mimicking that of natural infection but presenting little or no risk to the recipient?
What are the different forms of vaccines?
- live, attenuated microbes
- killed microbes or components of microbes
- killed whole agents
- extracts of microbes, such as soluble capsular polysaccharide
What is the term for an inactivated bacterial toxin that has lost its damaging properties but can still induce protective antibody responses?
- ex. diphtheria and tetanus toxins adsorbed onto aluminum salts
What is the term for administration of exogenously produced or preformed antibodies for the prevention or treatment of infectious disease?
What is the difference in timing of immune development between killed and live vaccines?
- killed - can take several weeks, often requiring 2-3 doses
- live - often develops w/in 2 weeks
What type of immunization usually has to be used postexposure?
- short incubation periods make active immunization ineffective
How long must live vaccine administration be delayed after passive immunization?
- average of 11 months
- takes that long for passive antibody to decay, which would otherwise inhibit normal immune response
The only cases of paralytic disease from polio in the united states occurs how?
- vaccine-acquired paralytic poliomyelitis
- from live vaccine
- 1 in 1-3 million doses
What parts of the immune system are recruited by live vaccine?
CD4, CD8, B cells
What parts of the immune system are recruited by killed or antigen vaccine?
CD4 and B cells
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