Molecular and Cellular Mechanisms Week 2
- Kansas City University of Medicine and Biosciences
- Biochemistry 1
- Molecular and Cellular Mechanisms Week 2
Last Modified: 2014-08-22
Remove receptor (eg. receptor removed in endosome
Remove and degrade receptor (eg. endosome to lysomes)
The ras independent pathway has PI 3 kinase which leads to protein phosphorylation and causes a change in protein and enzyme activity
G1/S cyclin (E): Helps the cells at the end of G1 phase to commit to DNA replication and enter S phase. Cyclin E-CDK2 complex
S phase cyclin (A): Necessary for the initiation of DNA synthesis. Cyclin A-CDK2 complex
M phase cyclins (A and B): Necessary for the nuclear division during mitosis. Cyclin A-CDK1 complex and Cyclin B-CDK1 complex
This process is activated by BAX and inhibited by BCL
v-Src is oncogene
c-Src is proto oncogene.
One example of monosomy that actually produces a living offspring. Usually result in short stature and webbed necks.
Trisomy 18, Edwards Syndrome: Clenched fist, short sternum, narrow pelvis, hypertelorism, short palpebral fissures, and rocker bottom feet.
Trisomy 21, Down syndrome. Mental retardation and pronounces forehead. reduced bridge of nose.
Slow phase - oocyte releases granules containing enzymes to degrade the sperm receptor proteins (zp3)
3 cavities: Amniotic space, Yolk sac, and chorion.
Cox 1 is constitutive.
Cox 2 is inducible. Exception in the renal system because it requires large response. Cox 2 is not made in platelets.
Vasculature: Causes Permeability
GI (Gut): Increases Mucosalcytoprotection, Muscle tone, Motility
Renal: Sodium and Water excretion
Uterus: Muscle contraction
PNS: Pain Sensitization
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