Reduction in number of RBC, decrease in hemoglobin concentration and/or decrease in hematocrit level!
1) excessive blood loss or 2) decreased production or increased destruction of RBC.
-It is what?
-Results from what?
-Pt develop clinical changes when hematocrit falls below what level? What are the clinical changes?
-Most of the symptoms are related to?
-What is uncommon and only seen in severe cases?
-Lab testing results?
-Histo: blood film shows what?
-The most common form of anemia!
1) chronic blood loss (most common etiology)
2) Inadequate dietary intake
3) Fault iron absorption i.e. Plummer-vinson syndrome
4) Increased requirement for iron, e.g. pregnancy, growing children
-Female sex prevalence!
-30%, fatigue, dizziness to pale skin, brittle and spoon-shaped fingernails (koilonychia).
-Low-oxygen levels due to decreased hemoglobin concentration!
- Smooth, red and painful tongue with atrophied papillae, generalized atrophy of oral mucosa and angular cheilitis.
-Pallor of oral mucosa
-low hemoglobin concentration, low serum iron, and elevated total iron binding capacity (TIBC).
-microcytic and hypochromic RBC’s.
-best to treat the underlying disease and supplement with iron and high protein diet
Plummer-Vinson Syndrome (Hysterical Dysphagia):
-Manifestation of what?
-Occurs mainly in who?
-Dz first termed as? later found to be due to an? Causes what?
-Predisposes to what?
-Describe clinical feature!
-Lab test show?
-Iron def anemia
-Northern European females!
-Hysterical dysphagia. Found to be due to esophageal stricture or WEB. which causes difficulty or painful swallowing!
-Predisposes to oral and esophageal SCC! KNOW
-Patients demonstrate clinical changes when hematocrit falls below 30%, which ranges from fatigue and dizziness to pale skin, brittle and spoon-shaped fingernails (koilonychia). Most of the symptoms are related to low-oxygen levels due to decreased hemoglobin concentration.
-The oral manifestations range from smooth, red and painful tongue with atrophied papillae, generalized atrophy of oral mucosa and angular cheilitis. Pale oral mucosa is uncommon and only seen in severe cases.
-Laboratory testing shows low hemoglobin concentration, low serum iron, elevated total iron binding capacity (TIBC).
-Blood film would show microcytic and hypochromic RBC’s. -Iron supplements and high protein diet.
What condition is considered a predisposing factor to oral and esophageal carcinoma?
Plummer-Vinson Syndrome (Hysterical Dysphagia)
Pernicious Anemia (Vit B12 anemia):
-Common or uncommon dz?
-resulting from? Leading to failure to secrete what?
-Def in what vitamin results in pernicious anemia?
-What symptoms to pt complain about?
-Pt are at risk for what?
-Histology of RBC?
-resulting from atrophy of gastric mucosa or post gastrectomy! Lead to failure in secretion of "intrinsic factor," needed for absorption of vitB12=pernicious anemia!
-Northern European descent!
-generalized weakness, numbness and tingling sensation of the extremities, pale skin and sclera (sometimes), loss of appetite and weight.
-Risk for Gastric Carcinoma!
-decreased hemoglobin concentration!
-glossitis, painful and burning tongue, ulceration, atrophy of papillae (tongue) and generalized atrophy of the oral mucosa.
-Decreased numbers of RBC’s with increase size (macrocytic, normochromic anemia).
-Monthly injections of the extrinsic factor; oral lesions heal shortly after the injections.