Generation of oxygen free radicals, mitochondrial damage, complement activation, or inflammation
Creatine kinase is a sign of:
Damage to heart, brain, skeletal muscle cells-->membrane damage
Hyperplasia occurs via:
Production of new cells from stem cells
Which are the only cell types that can't undergo hyperplasia? What do they do?
Permanent tissues can't do hyperplasia: cardiac muscle, skeletal muscle, nerves
They do hypertrophy instead
If pathologic, hyperplasia can-->__. What is one important exception?
Longstanding pathologic hyperplasia can progress to dysplasia and then to cancer (although hyperplasia itself is NOT premalignant). Exception: BPH, which is not at risk for progressing to cancer.
What is the mechanism of metaplasia? Is it reversible?
Reprogramming of stem cells to produce the cell type. Reversible if the stressor is remove. If not, can progress to dysplasia and next to cancer (the exception is apocrine metaplasia of the breast, which does not progress to cancer)