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University of Queensland
Pathology - Respiratory
Pathology - Respiratory
University of Queensland
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Acute pneumococcal lobar pneumonia
Left - Acute lobar pneumonia with alveolar spaces filled with inflammatory cells and fibrin and congested alveolar walls
Right - Lobar pneumonia in stage of resolution with small degenerated neutrophils (arrows) and large macrophages (arrowheads)
Organizing lobar pneumonia with maturing granulation tissue (arrows) within alveolar spaces
Acute bronchopneumonia. Note the small grey foci of consolidation (blue arrows) widely scattered through both lungs, which are hyperermic. Black arrows show pre-existing carbon deposition.
Inflammatory focus of bronchopneumonia. Cellular exudate (black arrows) is more prominent centrally with edema seen peripherally (blue arrows).
Staphylococcal pneumonia with lung abscess and pleurisy.
Lung abscesses (blue arrows) and fibrinous pleurisy (white arrows).
Melioidosis suppurative confluent bronchopneumonia due to Burkholderia pseudomallei.
Chronic lipid pneumonia. Lower lobe contains cystic spaces containing oily liquid.
Acute bronchopneumonia with bronchiectasis
Red arrows indicate ectatic bronchi
Blue arrows show possible abscess cavities
White arrows show bronchopneumonia
Severe fibrocystic disease
Red arrows show ectatic bronchi containing secretions and exudate
Blue arrows shoe areas of consolidation
Hyphae of Aspergillus stained with H&E (left) and silver stain (right)
Pneumocystis infection. Cysts seen in washing (bottom right).
Primary TB complex with Ghon focus (black arrow) under pleura in right upper lobe and extensive involvement of mediastinal lymph node with enlargement and caseation (red arrow).
Acute untreated pulmonary TB
Fibrocaseous subapical lesions (red arrows) and extensive spread of infection via the bronchi of TB bronchopneumonia (blue arrows).
Patcy acute non-TB bronchopneumonia (black arrows).
N = Zome of caseous necrosis
E = Epitheliod macrophages
Arrows = GIant cells
Arrows = Acid fast bacilli in a Ziehl-Neelsen stain
Caseating TB bronchopneumonia with TB granulomas in a bronchial distribution
Miliary TB with fibrocaseous lesion near right apex. Even distribution of granulomas.
Mucicarmine stain showing cryptococcal yeast forms (arrows).
Death from acute asthma
Obstruction of bronchi by mucus plugs (black arrows) and marked thickening of bronchial walls (red arrows)
Eosinophil infiltration into the wall of the bronchi
Large number of eosinophils
Centriacinar (centrilobular) emphysema
Severe panacinar emphysema with no fibrosis
Histology of emphysema showing reduced numbers of alveolar walls
Carcinoid tumor (red arrows) with obstruction, bronchiectasis (blue arrows) and infection.
Severe panacinar emphysema (white arrows) and chronic bronchitis with hypersecretion of mucus (red arrows).
Anthracosilicosis with progressive massive fibrosis (PMF) in upper love and silicotic nodules scattered throughout the rest of the lung parenchyma
Blue arrows = acute bronchopneumonia
Red arrows = carbon deposition
Silicotic nodules, rounded and located near bronchi and composed of dense collagen.
Red arrows = fibrocaseous TB
Black arrows = maximal fibrosis from asbestosis in lower lobes
Red arrows = Asbestosis in low power
Black arrows = Interstitial fibrosis
Black arrows = High power asbestos
Red arrows = Foreign body giant cells around asbestosis bodies
Calcified fibrous plaques in parietal pleura
Malignant pleural mesothelioma
Chronic passive venous congestion of the lung
Typical hyaline membranes (black arrows) derived from shed necrotic alveolar lining cells and exudate
Congestion in the alveolar walls (blue arrows)
Earlier stage of ARDS with proteinaceous exudate filling the airspaces
Severe atheroma of the pulmonary arteries (blue arrows) with extensive thrombosis
Congenital cystic disease of the left lower lobe and hypoplasia of the rest of the lung. Death occurred within the first few minutes after birth.
Bronchial cyst (containing red marker) which communicates with several bronchi. Emphysema. Pulmonary congestion. Small apical scars, probably due to old TB
Fibrous adhesions and focus of pleural calcification (red arrows) and small apical scar. Pulmonary congestion.
Organizing pneumonia (blue arrows) and pleurisy (red arrows)
Small cell carcinoma of lung (note central distribution)
Small cell carcinoma. Note small darkly staining cells with variable nuclear morphology and scant non-staining cytoplasm (nuclei twice diameter of lymphocyte nuclei)
Squamous cell carcinoma (red arrows) with lymph node mets
Partial collapse (blue arrows) and dilated bronchi (black arrows) filled with mucus in the upper lobe
Cavitating squamous cell carcinoma (black arrows) in the lung with associated bronchiectasis and endogenous lipid pneumonia (red arrows)
Carcinoma of lung
Red arrows = alveoli line by regular, columnar, mucus secreting epithelial cells. Histologically looks like "bronchioloalveolar cell" carcinoma
Black arrows = more solid poorly differentiated tumor cells
Undifferentiated bronchogenic carcinoma with extensive mediastinal lymph node mets.
Red arrows = trachea
Blue arrows = aorta
Left bronchogenic carcinoma of undifferentiated (oat cell or small cell) type with extensive pulmonary infiltration.
Red arrows = peribronchial spread in this form of bronchogenic carcinoma
Black arrows = Thickened pleura and severe acute pleurisy
Carcinoid tumour (red arrow) with obstruction, bronchiectasis (blue arrow) and infection
Permeation of peribronchial pulmonary lymphatics by metastatic gastric carcinoma, often referred to as lymphagitis carcinomatosa
Blood-borne metastatic neuroblastoma in the lung
Acute laryngo-tracheo-bronchitis with reddening of the epiglottis.
Acute epiglottitis, noting the edema and congestion.
laryngo-tracheal membranous diptheria
Diptheria leading to tonsil swelling and inflammation leading to obstruction and death
Tracheostomy scar above the supra sternal notch
Larynx obstruction by large piece of meat
Carcinoma of the larynx
Advanced well differentiated squamous cell carcinoma of the larynx (black arrows)
Tracheotomy (black arrow) with ulceration of the tracheal mucosa (red arrows)
Post-traumatic stricture (black arrow) of the trachea
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