Last Modified: 2011-11-01
2. PKA phosphorylates CREB (+ATP, -ADP)
3. phosphorylated CREB binds to CBP
4. transcription is activated
2. DAG stays in plasma membrane and with Ca, ATP and other proteins activates PKC
3. PKC decreases calcium current by regulating Ca channels
Binds to and activates ligand sensitive calcium channels
Causes influx of Ca from ER to cytoplasm
Ca helps DAG activate PKC
**cGMP also produces GMP and CNG
w/o Hh, Patched inhibits smoothened, PKA and Slimb cause phosphorylation & cleavage of Ci→ Ci represses transcription
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