Prokaryotic DNA Repair
Last Modified: 2011-11-10
-cleaves dimer in blue light's presence
-binds to it, cuts just base from nucleotide
-recruits AP-endonuclease to cleave backbone
-nick in DNA has DPol1 replace nucleotide and lygase patches nick
-with ATP, causes release of UVR-A dimer, and UVR-B will bend DNA
-UVR-C nicks DNA, at 5' and 3', of 24 bases
-UVR-D (helicase) unzips and releases dimer
-Pol 1 or 2 patches, and ligase patches nick
-recruits MUT-L, MUT-H, and
-recruits helicase to remove mismatch and around 24 bases
-Pol II comes to synthesize new strand, and ligase patches nick
-RecA binds DNA complex, unzips new strand, and has it degraded
-gets old strands to rezip and displace the 2nd new strand
-only if during synthesis, it encounters mutagens
-RecA binds, recruits Pol V, and UmuD
-Pol V finds lesion, and synthesizes DNA
~makes decision on what base to add (1 in 4 chance of getting it right)
-Pol III comes back to finish replication
-another method will come along to fix the mutation that's still there
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