Stress; it tends to pop up in localized areas of trauma
Are there any signs on the fingernails of psoriasis?
yes - pitting.
What is on the differential for a suspected case of psoriasis?
Perhaps seborrheic dermatitis (scalp), eczema, psoriasiform drug eruption.
How common is psoriasis in the population as compared to atopic dermatits?
2% vs. 15%. Psoriasis incidence occurs more in older individuals
Is there a genetic component to psoriasis?
Yes - some sort of polygenetic phenomenon
Besides affecting the skin, are there other effects on the body from psoriasis?
8-10% will have an associated arthritis: small joints of the hands and feet or large joints of the legs. Or both
Why do plaques form in psoriasis?
For some reason (cytokines, other factors), the keratinocyte lifecycle is greatly accelerated. Instead of going from startum basalis --> shedding in 28 days, it can go as quickly as 6 days. The scale is the accumulation of these cells in the stratum corneum
Where as AD is more of a th-2 related disorder, what is psoriasis?
A TH-1 dominated disorder with involvement of Th17.
What cytokines do Th-17 cells release to stimulate keratinocytes? What cytokine stimulates Th-17 cells?
IL-2 (from TH-1)
Describe the vascularization in the psoriatic plaques
Very well vascularized. Scraping them off would cause a real bleeder.