SEQ CHAPTER \h \r 1 EEOB 410 - Transport of Oxygen in Blood Question Set 11 Reading: Chapter 23, pp. 587-596, 600 The oxygen equilibrium curve (oxygen dissociation curve) for hemoglobin rises steeply, then plateaus. What are the functional reasons for this shape? The oxygen equilibrium curve can shift to the left or right under various circumstances. What is the effect of such a shift on O2 binding? What is the effect of left and right shifts of the oxygen equilibrium curve on oxygen uptake in the lungs and oxygen release in the tissues? Would you expect the hemoglobin of a fetus to have a higher or lower P50 than that of the mother carrying the fetus? When a tissue is active (and therefore using more O2), it tends to produce a greater amount of CO2, to increase the local tissue acidity, and to elevate the local tissue temperature. What effects do these changes have on the binding of O2 by hemoglobin and is this adaptive? Animals can shift their oxyhemoglobin curve left or right in response to chronic demands. How do they do control the P50 of their blood? Evolution can adjust the oxygen dissociation curve to meet the demands of the organism. Would you expect the oxygen equilibrium curve for small animals to have a higher or lower P50? To achieve neutral buoyancy, bony fish adjust the size of their swim bladder, which is filled with oxygen. How do they fill their swim bladder with O2 against the huge pressure exerted by the water column above them?